{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:50:07Z","timestamp":1782211807966,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T00:00:00Z","timestamp":1471910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transplant patients are at increased risk for developing severe norovirus (NoV) infections with secondary complications such as rejection episodes and acute transplant failure.<\/jats:p><jats:p>This single\u2010center retrospective study included all kidney transplant patients tested positive for NoV RNA between January 2007 and December 2011. Data were compared to a control group of 528 kidney transplant patients without NoV infection.<\/jats:p><jats:p>Sixty\u2010five kidney transplant patients were recorded NoV RNA positive. Of these, 26 patients (40%) presented with acute transplant failure (AKI). In 43 patients (66.2%), dose reduction in immunosuppression was performed, and of 22 patients receiving tacrolimus, four patients (18.2%) showed toxic trough levels above 15\u00a0ng\/mL at time of diagnosis. In three patients (4.6%), indicated therapeutic procedures had to be postponed due to prolonged severe diarrhea. Ten patients (15.4%) developed chronic NoV infection. One\u2010year patient and graft survival in NoV patients and controls was 92.3% and 96.4%, respectively (n.s.).<\/jats:p><jats:p>Compared to controls, eGFR was already significantly lower before NoV infection and loss of eGFR relative to baseline over 12 and 36\u00a0months was significantly higher in NoV\u2010infected patients. In particular, patients initially presenting with AKI experienced a long\u2010term loss of transplant function. Risk factors for NoV infection were immunosuppression containing steroids and antirejection therapy.<\/jats:p>","DOI":"10.1111\/ctr.12820","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T14:42:36Z","timestamp":1469198556000},"page":"1283-1293","source":"Crossref","is-referenced-by-count":15,"title":["Clinical outcome of norovirus infection in renal transplant patients"],"prefix":"10.1111","volume":"30","author":[{"given":"Susanne","family":"Brakemeier","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Charit\u00e9 Campus Mitte  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Styliani I.","family":"Taxeidi","sequence":"additional","affiliation":[{"name":"Department of Hematology Charite Campus Mitte  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"D\u00fcrr","sequence":"additional","affiliation":[{"name":"Division of 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