{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:37:54Z","timestamp":1788521874041,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T00:00:00Z","timestamp":1473984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Abstract<\/jats:title>The low sensitivity of C4d immunoreactivity in peritubular capillaries (PTC<\/jats:styled-content>s) hinders its use in the diagnosis of chronic active antibody\u2010mediated rejection (CAAMR<\/jats:styled-content>). C4d\u2010negative CAAMR<\/jats:styled-content> was defined in the 2013 Banff classification, which included the expression of endothelial\u2010associated transcripts (ENDAT<\/jats:styled-content>s). We previously showed that the ENDAT<\/jats:styled-content> caveolin\u20101 (CAV<\/jats:styled-content>\u20101) is a distinct feature of CAAMR<\/jats:styled-content>. In this study, we investigated the prognostic value of CAV<\/jats:styled-content>\u20101 immunoreactivity in PTC<\/jats:styled-content>s in kidney transplant patients. Ninety\u2010eight kidney transplant recipients were included in this study. The prognostic value of CAV<\/jats:styled-content>\u20101 immunoreactivity in PTC<\/jats:styled-content>s was evaluated by double immunostaining for CAV<\/jats:styled-content>\u20101 and pathologische Anatomie Leiden endothelium (PAL<\/jats:styled-content>\u2010E, a PTC<\/jats:styled-content> marker) in the PTC<\/jats:styled-content>s of kidney allograft biopsy samples. The patients were divided into two groups: CAV<\/jats:styled-content>\u20101\/PAL<\/jats:styled-content>\u2010E<50% and CAV<\/jats:styled-content>\u20101\/PAL<\/jats:styled-content>\u2010E\u226550%. Kaplan\u2010Meier curves showed that CAV<\/jats:styled-content>\u20101\/PAL<\/jats:styled-content>\u2010E\u226550% patients had a significantly worse prognosis than that of CAV<\/jats:styled-content>\u20101\/PAL<\/jats:styled-content>\u2010E<50% patients (log\u2010rank; P<\/jats:italic><.001). C4d staining of PTC<\/jats:styled-content>s was not associated with the development of graft failure (log\u2010rank; P<\/jats:italic>=.345), whereas in a multivariate Cox regression analysis, CAV<\/jats:styled-content>\u20101 immunoreactivity in PTC<\/jats:styled-content>s was independently associated with graft failure (hazard ratio: 11.1; P<\/jats:italic>=.0324). CAV<\/jats:styled-content>\u20101 immunoreactivity in PTC<\/jats:styled-content>s may serve as a prognostic marker for kidney allograft survival.<\/jats:p>","DOI":"10.1111\/ctr.12833","type":"journal-article","created":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T11:06:42Z","timestamp":1471691202000},"page":"1417-1424","source":"Crossref","is-referenced-by-count":12,"title":["The prognostic values of caveolin\u20101 immunoreactivity in peritubular capillaries in patients with kidney transplantation"],"prefix":"10.1111","volume":"30","author":[{"given":"Yasuyuki","family":"Nakada","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension Department of Internal Medicine The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Department of Internal Medicine The Jikei University School 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