{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:52:37Z","timestamp":1790419957059,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T00:00:00Z","timestamp":1475452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Abstract<\/jats:title>ABO<\/jats:styled-content> blood group antigen incompatibility (ABO<\/jats:styled-content> mismatch) is not an obstacle to allogeneic stem cell transplantation (allo\u2010SCT<\/jats:styled-content>). However, the impact on clinical outcome after allo\u2010SCT<\/jats:styled-content> remains controversial. We analyzed 512 patients after allogeneic peripheral blood SCT<\/jats:styled-content> (allo\u2010PBSCT<\/jats:styled-content>) for an association of ABO<\/jats:styled-content> mismatch with transfusion requirements, myeloid and platelet engraftment, the incidence of GvHD<\/jats:styled-content>, relapse, transplant\u2010related mortality (TRM<\/jats:styled-content>), and overall survival (OS<\/jats:styled-content>). A total of 260 patients underwent ABO<\/jats:styled-content>\u2010mismatched transplantation and the control group consisted of 252 patients with ABO<\/jats:styled-content>\u2010matched allo\u2010PBSCT<\/jats:styled-content>. We found a significant association between major\u20100 ABO<\/jats:styled-content> mismatch (group 0 recipient\/group A, B, or AB<\/jats:styled-content> donor) and increased red blood cell (RBC<\/jats:styled-content>) and platelet transfusion requirements (both P<\/jats:italic><.001) as well as delayed platelet engraftment (P<\/jats:italic><.001). Minor\u2010A (group A recipient\/group 0 donor) and minor\u2010AB<\/jats:styled-content> (group AB<\/jats:styled-content> recipient\/group 0, A, or B donor) ABO<\/jats:styled-content> mismatch was significantly associated with an increased TRM<\/jats:styled-content> after allo\u2010PBSCT<\/jats:styled-content> (P<\/jats:italic>=.001 and P<\/jats:italic>=.02). In multivariate analysis performed using Cox regression, minor ABO<\/jats:styled-content> mismatch appeared as independent risk factor for TRM<\/jats:styled-content> after allo\u2010PBSCT<\/jats:styled-content>. No association was found for ABO<\/jats:styled-content> mismatch with the incidence of GvHD<\/jats:styled-content>, relapse, and OS<\/jats:styled-content>. Our results suggest that ABO<\/jats:styled-content> blood group mismatch has a significant impact on the outcome and that minor\u2010A and minor\u2010AB ABO<\/jats:styled-content> mismatch represents a risk factor for increased TRM<\/jats:styled-content> after allo\u2010PBSCT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ctr.12840","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T15:36:59Z","timestamp":1473694619000},"page":"1457-1465","source":"Crossref","is-referenced-by-count":12,"title":["ABO<\/scp> blood group antigen mismatch has an impact on outcome after allogeneic peripheral blood stem cell transplantation"],"prefix":"10.1111","volume":"30","author":[{"given":"Matthias","family":"Grube","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, Hematology and Oncology University Hospital Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wolff","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Hematology and Oncology University Hospital Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Ahrens","sequence":"additional","affiliation":[{"name":"Institute for Laboratory and Transfusion Medicine University Hospital Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp Y.","family":"Herzberg","sequence":"additional","affiliation":[{"name":"Department of Personality Psychology and Psychological Assessment Helmut\u2010Schmidt\u2010University\/University of the German Federal Armed Forces Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Herr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, 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