{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:47:25Z","timestamp":1787921245133,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T00:00:00Z","timestamp":1478563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Beatty Liver and Obesity Research Fund"},{"name":"Liver Outcomes Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection is often considered a contraindication for receiving a heart transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From the Scientific Registry of Transplant Recipients, we selected all adults with and without <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection who underwent a single\u2010organ heart transplantation in 1995\u20102013; the mortality status was updated in September 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 32\u00a0812 heart transplant recipients were included; N=756 (2.30%) <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> positive. Post\u2010transplant patients were discharged alive at similar rates regardless of their <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> status (<jats:italic>P<\/jats:italic>=.10). Despite this, mortality in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>+ heart transplant recipients was consistently higher throughout post\u2010discharge follow\u2010up (<jats:italic>P<\/jats:italic>&lt;.002). In multivariate survival analysis, being <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>+ was independently associated with a higher post\u2010transplant mortality: adjusted hazard ratio 1.35 (1.16\u20101.56), <jats:italic>P<\/jats:italic>&lt;.0001. Other predictors of lower post\u2010transplant survival included being obese at transplant and pre\u2010transplant history of comorbidities (type 2 diabetes, <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>, hypertension) (all <jats:italic>P<\/jats:italic>&lt;.05). No association of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection with graft loss rates or time to graft loss was found (all <jats:italic>P<\/jats:italic>&gt;.23).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chronic hepatitis C infection is associated with a significantly increased post\u2010transplant mortality in heart transplant recipients. The introduction of new direct\u2010acting antiviral agents may provide a treatment option for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> pre\u2010 or post\u2010heart transplantation which could have a positive impact on patients' survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12859","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T07:57:42Z","timestamp":1476431862000},"page":"1570-1577","source":"Crossref","is-referenced-by-count":21,"title":["Long\u2010term outcomes of heart transplant recipients with hepatitis C positivity: the data from the U.S. transplant registry"],"prefix":"10.1111","volume":"30","author":[{"given":"Maria","family":"Stepanova","sequence":"first","affiliation":[{"name":"Betty and Guy Beatty Center for Integrated Research Inova Health System  Falls Church VA USA"},{"name":"Center for Outcomes Research in Liver Diseases  Washington DC 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