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A supraphysiologic level of fibroblast growth factor 23 (<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023) has been associated with myocardial hypertrophy in this patient population. Our aim was to evaluate the change in cardiac morphology and function following kidney transplantation and to evaluate the association between the change in <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023 concentrations and cardiac morphology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a longitudinal, prospective cohort study of 143 kidney transplant recipients (73% male, 75% white) measuring left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) mass index, left atrial (<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>) volume index, and ejection fraction (<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>) by echocardiography at months 1, 12, and 24 post\u2010transplant. <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023 levels were measured at months 1 and 24 post\u2010transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Unadjusted and adjusted linear mixed\u2010effects models were used to examine changes in outcomes over time. In the adjusted model, <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> mass index (<jats:italic>P<\/jats:italic>&lt;.001) and <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> volume index (<jats:italic>P<\/jats:italic>&lt;.001) decreased and <jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content> (<jats:italic>P<\/jats:italic>=.009) increased significantly over time. There was a significant association between decreasing <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023 levels and improving <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> mass index following transplant (<jats:italic>P<\/jats:italic>=.036) in the unadjusted model; however, there was no significant relationship in the adjusted model (0.195).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Understanding the progression of unique cardiovascular risk factors associated with kidney transplantation may provide potential opportunities to improve survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12864","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T09:46:39Z","timestamp":1479980799000},"source":"Crossref","is-referenced-by-count":12,"title":["Longitudinal assessment of cardiac morphology and function following kidney transplantation"],"prefix":"10.1111","volume":"31","author":[{"given":"Clark","family":"Kensinger","sequence":"first","affiliation":[{"name":"Department of Surgery Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Clinical Anesthesiology Division of Critical Care Medicine and Cardiothoracic Anesthesiology Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aihua","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meagan","family":"Fairchild","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanhua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loren","family":"Lipworth","sequence":"additional","affiliation":[{"name":"Division of Epidemiology Department of Medicine Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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