{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:29:58Z","timestamp":1782937798872,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T00:00:00Z","timestamp":1480032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Complement component 3 (C3) presents both slow (C3S) and fast (C3F) variants, which can be locally produced and activated by immune system cells. We studied C3 recipient variants in 483 liver transplant patients by <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content> to determine their effect on graft outcome during the first year post\u2010transplantation. Allograft survival was significantly decreased in C3<jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content> recipients (C3<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> 95% vs C3<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> 91% vs C3<jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content> 83%; <jats:italic>P<\/jats:italic>=.01) or C3F allele carriers (C3F absence 95% vs C3F presence 90%, <jats:italic>P<\/jats:italic>=.02). C3<jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content> genotype or presence of C3F allele independently increased risk for allograft loss (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 2.38, <jats:italic>P<\/jats:italic>=.005 and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 2.66, <jats:italic>P<\/jats:italic>=.02, respectively). C3<jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content> genotype was more frequent among patients whose first infection was of viral etiology (C3<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> 13% vs C3<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> 18% vs C3<jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content> 32%; <jats:italic>P<\/jats:italic>=.04) and independently increased risk for post\u2010transplant viral infections (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3.60, <jats:italic>P<\/jats:italic>=.008). On the other hand, C3<jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content> and C3F protected from rejection events (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.54, <jats:italic>P<\/jats:italic>=.03 and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.63, <jats:italic>P<\/jats:italic>=.047, respectively). Differences were not observed in hepatitis C virus recurrence or patient survival. In conclusion, we show that, independently from C3 variants produced by donor liver, C3F variant from recipient diminishes allograft survival, increases susceptibility to viral infections, and protects from rejection after transplantation. C3 genotyping of liver recipients may be useful to stratify risk.<\/jats:p>","DOI":"10.1111\/ctr.12866","type":"journal-article","created":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T11:03:07Z","timestamp":1480071787000},"source":"Crossref","is-referenced-by-count":8,"title":["Complement C3F allotype synthesized by liver recipient modifies transplantation outcome independently from donor hepatic C3"],"prefix":"10.1111","volume":"31","author":[{"given":"Diana Mar\u00eda","family":"Valero\u2010Herv\u00e1s","sequence":"first","affiliation":[{"name":"Department of Immunology Hospital 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"S\u00e1nchez\u2010Zapardiel","sequence":"additional","affiliation":[{"name":"Department of Immunology Hospital 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Immunology Hospital 12 de Octubre  Madrid Spain"},{"name":"I+12 Research Institute Hospital 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Gallego\u2010Bustos","sequence":"additional","affiliation":[{"name":"Department of Immunology Hospital 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"Cambra","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery and Abdominal Organ Transplantation Hospital 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iago","family":"Justo","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery and Abdominal Organ Transplantation Hospital 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Laguna\u2010Goya","sequence":"additional","affiliation":[{"name":"Department of Immunology Hospital 12 de Octubre  Madrid Spain"},{"name":"I+12 Research Institute Hospital 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Jim\u00e9nez\u2010Romero","sequence":"additional","affiliation":[{"name":"I+12 Research Institute Hospital 12 de Octubre  Madrid Spain"},{"name":"Department of General and Digestive Surgery and Abdominal Organ Transplantation Hospital 12 de Octubre  Madrid Spain"},{"name":"School of Medicine Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Moreno","sequence":"additional","affiliation":[{"name":"I+12 Research Institute Hospital 12 de Octubre  Madrid Spain"},{"name":"Department of General and Digestive Surgery and Abdominal Organ Transplantation Hospital 12 de Octubre  Madrid Spain"},{"name":"School of Medicine Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"L\u00f3pez\u2010Medrano","sequence":"additional","affiliation":[{"name":"I+12 Research Institute Hospital 12 de Octubre  Madrid Spain"},{"name":"Unit of Infectious Diseases Hospital 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"San Juan","sequence":"additional","affiliation":[{"name":"I+12 Research Institute Hospital 12 de Octubre  Madrid Spain"},{"name":"Unit of Infectious Diseases Hospital 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Fern\u00e1ndez\u2010Ruiz","sequence":"additional","affiliation":[{"name":"I+12 Research Institute Hospital 12 de Octubre  Madrid Spain"},{"name":"Unit of Infectious Diseases Hospital 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Aguado","sequence":"additional","affiliation":[{"name":"I+12 Research Institute Hospital 12 de Octubre  Madrid Spain"},{"name":"School of Medicine Universidad Complutense de Madrid  Madrid Spain"},{"name":"Unit of Infectious Diseases Hospital 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Paz\u2010Artal","sequence":"additional","affiliation":[{"name":"Department of Immunology Hospital 12 de Octubre  Madrid Spain"},{"name":"I+12 Research Institute Hospital 12 de Octubre  Madrid Spain"},{"name":"School of Medicine Universidad Complutense de Madrid  Madrid Spain"},{"name":"Section of Immunology Universidad San Pablo CEU  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105904"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.4.1011"},{"key":"e_1_2_7_4_1","first-page":"1564","article-title":"Molecular analysis of C3 allotypes in patients with systemic vasculitis","volume":"9","author":"Finn JE","year":"1994","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb05917.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000152575"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00291406"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-3231"},{"key":"e_1_2_7_9_1","first-page":"105","article-title":"CFH haplotypes and ARMS2, C2, C3, and CFB alleles show association with susceptibility to age\u2010related macular degeneration in Mexicans","volume":"20","author":"Contreras AV","year":"2014","journal-title":"Mol Vis"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072618"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.211144"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019338108"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.018"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.02.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2013.08.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2011.06.004"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.4580"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121525"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2499"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01315"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1917"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052825"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801861"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.01.062"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21972"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1721727X1201000308"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2307\/2983604"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250328"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0402-373"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.2.788"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.5158"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300847"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:04:39Z","timestamp":1696302279000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,25]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/ctr.12866"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12866","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,25]]},"article-number":"e12866"}}