{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:45:20Z","timestamp":1793335520678,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T00:00:00Z","timestamp":1484092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Due to the severe organ shortage and the increasing gap between the supply and demand for donor grafts, live donor liver transplantation (<jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>) has become an accepted and alternative technique for the expansion of the donor pool. However, donor safety and good recipient outcomes must be balanced regarding risk stratification and decision\u2010making within this patient population. Small\u2010for\u2010size syndrome (<jats:styled-content style=\"fixed-case\">SFSS<\/jats:styled-content>) is one of the complications encountered after <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>, thus increasing the burden of optimizing donor graft selection and effective treatments during its occurrence. A graft\u2010to\u2010recipient weight ratio (<jats:styled-content style=\"fixed-case\">GRWR<\/jats:styled-content>) &lt;0.8 predisposes the graft to <jats:styled-content style=\"fixed-case\">SFSS<\/jats:styled-content>. However, other factors may induce this complication even without a graft\u2010to\u2010patient size mismatch. Several strategies to prevent this complication include portal vein flow and liver outflow modulation, as well as pharmacological treatment. Also, as an entity with a multifactorial etiology, outcomes vary between right\u2010lobe, left\u2010lobe, and posterior\u2010lobe donation among series encountered in the literature. In this review, we analyze the pathophysiology and classification of this complication, the state\u2010of\u2010the\u2010art on management of <jats:styled-content style=\"fixed-case\">SFSS<\/jats:styled-content>, and the outcomes regarding the best treatment strategy on this patient population.<\/jats:p>","DOI":"10.1111\/ctr.12885","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T19:35:26Z","timestamp":1481312126000},"source":"Crossref","is-referenced-by-count":33,"title":["Small\u2010for\u2010size syndrome in live donor liver transplantation\u2014Pathways of injury and therapeutic strategies"],"prefix":"10.1111","volume":"31","author":[{"given":"Nicolas","family":"Goldaracena","sequence":"first","affiliation":[{"name":"Multi Organ Transplant Program Department of Surgery Toronto General Hospital  Toronto Ontario 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