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Combined heart\u2010liver transplantation (<jats:styled-content style=\"fixed-case\">CHLT<\/jats:styled-content>) is an option for select patients although limited data exist on this strategy. A retrospective review of Fontan patients 18\u00a0years or older referred for cardiac transplant evaluation between 2000 and 2013 at the Hospital of the University of Pennsylvania was performed. All patients were considered for potential <jats:styled-content style=\"fixed-case\">CHLT<\/jats:styled-content>. Clinical variables such as demographics, perioperative factors, and short\u2010term outcomes were reviewed. Of 17 referrals for cardiac transplantation, seven Fontan patients underwent <jats:styled-content style=\"fixed-case\">CHLT<\/jats:styled-content>. All patients who underwent <jats:styled-content style=\"fixed-case\">CHLT<\/jats:styled-content> had either advanced fibrosis or cirrhosis on liver biopsy. There were no perioperative deaths. The most common postoperative morbidity was acute kidney injury. Short\u2010term complications include one episode of acute liver rejection but no cardiac rejection greater than 1R. <jats:styled-content style=\"fixed-case\">CHLT<\/jats:styled-content> is an acceptable therapeutic option for patients with failing Fontan physiology who exhibit concomitant advanced liver fibrosis. However, optimal patient selection is currently undefined, and long\u2010term outcomes are not known.<\/jats:p>","DOI":"10.1111\/ctr.12892","type":"journal-article","created":{"date-parts":[[2016,12,18]],"date-time":"2016-12-18T04:42:56Z","timestamp":1482036176000},"source":"Crossref","is-referenced-by-count":74,"title":["Single\u2010center outcomes of combined heart and liver transplantation in the failing Fontan"],"prefix":"10.1111","volume":"31","author":[{"given":"Benjamin A.","family":"D'Souza","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine Hospital of the University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Fuller","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Department of Surgery The Children's Hospital of Philadelphia  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lacey 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