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Based on this test, a non\u2010invasive clinical algorithm was implemented since 2005. After clinical implementation, this <jats:styled-content style=\"fixed-case\">GEP<\/jats:styled-content>\u2010based monitoring in direct comparison with an <jats:styled-content style=\"fixed-case\">EMB<\/jats:styled-content>\u2010based strategy was non\u2010inferior with respect to detection of clinical rejection, defined as new onset allograft dysfunction with\/without histology of <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content>, re\u2010transplantation or death, and at the same time improved patient satisfaction. Subsequently, we demonstrated the test's capacity when used as serial monitoring tool to predict these clinical rejection events. In this Personal Viewpoint article, I will discuss the various decision\u2010making branching points that were made in the AlloMap biomarker test development to inform future genomic biomarker test development projects.<\/jats:p>","DOI":"10.1111\/ctr.12900","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T07:51:10Z","timestamp":1486108270000},"source":"Crossref","is-referenced-by-count":34,"title":["The AlloMap\u2122 genomic biomarker story: 10 years after"],"prefix":"10.1111","volume":"31","author":[{"given":"Mario C.","family":"Deng","sequence":"first","affiliation":[{"name":"Advanced Heart Failure\/Mechanical Support\/Heart Transplant David Geffen School of Medicine at UCLA Ronald Reagan UCLA Medical Center  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35057062"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058040"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199511270-00011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.6.1647"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199805150-00018"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)00085-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.05.034"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01175.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01305.x"},{"key":"e_1_2_9_11_1","first-page":"587","article-title":"A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. 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