{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:45:02Z","timestamp":1787053502798,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The current recommendation for the treatment of latent tuberculosis infection (<jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content>) in solid organ transplant candidates is isoniazid for 9\u00a0months, but this treatment has the main problem of frequently reaching the posttransplant period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is the study of efficacy and safety of a 3\u2010month regimen with isoniazid and rifampicin (3<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) in lung transplant candidates in the Reina Sof\u00eda Hospital in C\u00f3rdoba.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and ninety\u2010eight lung transplant patients were evaluated. Ninety\u2010two (24.9%) had <jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content> and just 22 received the 3<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> treatment. One additional patient was treated because he had a history of previous incomplete treatment for active <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>. None of the treated patients developed posttransplant tuberculosis compared to three of the 62 patients with <jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content> who were not treated (4.8%). Three patients could not conclude the 3<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> treatment (13%), but only two had adverse effects (8.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment of <jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content> in lung transplant candidates using a short course of 3<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> appears to be effective and safe in preventing posttransplant <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> in lung transplant recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12901","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T20:07:25Z","timestamp":1482610045000},"source":"Crossref","is-referenced-by-count":13,"title":["Efficacy and safety of short\u2010term treatment with isoniazid and rifampicin for latent tuberculosis infection in lung transplant candidates"],"prefix":"10.1111","volume":"31","author":[{"given":"Emilio","family":"Guirao\u2010Arrabal","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC) Universidad de C\u00f3rdoba (UCO)  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Santos","sequence":"additional","affiliation":[{"name":"Thoracic Surgery and Lung Transplantation Unit Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Redel","sequence":"additional","affiliation":[{"name":"Thoracic Surgery and Lung Transplantation Unit Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Vaquero","sequence":"additional","affiliation":[{"name":"Thoracic Surgery and Lung Transplantation Unit Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Torre\u2010Cisneros","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC) Universidad de C\u00f3rdoba (UCO)  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/597590"},{"key":"e_1_2_8_3_1","first-page":"CD007545","article-title":"Rifamycins (rifampicin, rifabutin and rifapentine) compared to isoniazid for preventing tuberculosis in HIV\u2010negative people at risk of active 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