{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:27:55Z","timestamp":1781684875783,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metabolic syndrome (MetS) is a known complication after hematopoietic stem cell transplantations (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) that contributes to long\u2010term morbidity. We assessed the prevalence of components of the MetS in pediatric survivors of allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> and identified associated risk factors. Thirty\u2010eight patients, median age at <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, 8.5\u00a0years, were evaluated at a median of 3.9\u00a0years post\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. Overweight or obesity was seen in 23.7% of the patients, 15.8% had hypertension, 15.8% had hypertriglyceridemia, and 13% had low high\u2010density lipoprotein cholesterol levels according to age and gender. Four (10.5%) met the criteria of MetS; all were transplanted for malignant disease. Twelve patients (31.6%) had at least one component of the MetS. The 5\u2010year probability of developing components of the MetS revealed that patients with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u2010<jats:italic>Z<\/jats:italic> score \u22650 at <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> were significantly at higher risk than those with lower <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u2010<jats:italic>Z<\/jats:italic>. Patients who developed components of the MetS had higher levels of insulin, homeostasis model assessment, uric acid, leptin, and lower adiponectin levels. Multivariable regression analysis revealed that <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u2010<jats:italic>Z<\/jats:italic>\u2010score &gt;1.036 at time of evaluation was associated with 4.3\u2010fold increased risk (<jats:italic>P<\/jats:italic>=.050) and adiponectin levels \u22646\u00a0\u03bcg\/mL were associated with 6.7\u2010fold increased risk of develop components of the MetS (<jats:italic>P<\/jats:italic>=.007). Overweight and obesity and adiponectin levels may be useful as markers in <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> survivors.<\/jats:p>","DOI":"10.1111\/ctr.12903","type":"journal-article","created":{"date-parts":[[2016,12,31]],"date-time":"2016-12-31T07:56:40Z","timestamp":1483171000000},"source":"Crossref","is-referenced-by-count":26,"title":["The metabolic syndrome and its components in pediatric survivors of allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"31","author":[{"given":"Bella","family":"Bielorai","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology and BMT Sheba Medical Center  Tel\u2010Hashomer Ramat\u2010Gan Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Pediatric Endocrinology and Diabetes Unit The Edmond and Lily Safra Children's Hospital Sheba Medical Center  Tel\u2010Hashomer Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphna","family":"Hutt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology and BMT Sheba Medical Center  Tel\u2010Hashomer Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Hemi","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology Sheba Medical Center  Tel\u2010Hashomer Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Kanety","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology Sheba Medical Center  Tel\u2010Hashomer Ramat\u2010Gan 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