{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:27:14Z","timestamp":1753878434855,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T00:00:00Z","timestamp":1487548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the health impact of nephrectomy on living kidney donors (<jats:styled-content style=\"fixed-case\">LKD<\/jats:styled-content>s) by comparing the health\u2010related quality of life (HrQOL) scores measured by Short Form\u201036 (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>36) between those with and without postdonation renal function impairment (<jats:styled-content style=\"fixed-case\">PRFI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010two<jats:styled-content style=\"fixed-case\">LKD<\/jats:styled-content>s (47 females, mean age=50.2\u00b111.2\u00a0years) were prospectively recruited to participate in a<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036 Hr<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>survey. Chart review, individual baseline, and postoperative renal function (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>) was determined using the Modification of Diet in Renal Disease formula.<jats:styled-content style=\"fixed-case\">PRFI<\/jats:styled-content>was defined as<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>&lt;60\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>or proteinuria. Mean<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036 domain scores were compared between those with and without PRFI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a median follow\u2010up of 5.7\u00a0years, the prevalence of postdonation comorbidities was 29.3% (n=24)<jats:styled-content style=\"fixed-case\">PRFI<\/jats:styled-content>, 25.6% (n=21) hypertension, 6.1% (n=5) diabetes, and 3.7% (n=3) heart disease, and no<jats:styled-content style=\"fixed-case\">LKD<\/jats:styled-content>s developed end\u2010stage renal disease. Mean<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>before and after donor nephrectomy was 95.5\u00b123.4 and 71.0\u00b117.3\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>(<jats:italic>P<\/jats:italic>&lt;.01). Mean<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036 scores of<jats:styled-content style=\"fixed-case\">LKD<\/jats:styled-content>s were not significantly different between those with and without<jats:styled-content style=\"fixed-case\">PRFI<\/jats:styled-content>in all the domains (all<jats:italic>P<\/jats:italic>&gt;.05). Similarly, the proportion of<jats:styled-content style=\"fixed-case\">LKD<\/jats:styled-content>s with<jats:styled-content style=\"fixed-case\">PRFI<\/jats:styled-content>did not differ significantly between the patients with<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036 domain scores above and below the published reference values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nephrectomy\u2010induced<jats:styled-content style=\"fixed-case\">PRFI<\/jats:styled-content>may not have a significant impact on the Hr<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>of the<jats:styled-content style=\"fixed-case\">LKD<\/jats:styled-content>population with a low proportion of other major comorbidities such as diabetes and ischemic heart disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12910","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T15:45:37Z","timestamp":1484322337000},"source":"Crossref","is-referenced-by-count":3,"title":["Nephrectomy\u2010induced reduced renal function and the health\u2010related quality of life of living kidney donors"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8055-9987","authenticated-orcid":false,"given":"Xiao","family":"Han","sequence":"first","affiliation":[{"name":"Department of Urology National University Hospital National University Health System Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel Yu Ming","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Urology National University Hospital National University Health System Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lata","family":"Raman","sequence":"additional","affiliation":[{"name":"Department of Urology National University Hospital National University Health System Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bee Choo","family":"Tai","sequence":"additional","affiliation":[{"name":"Saw Swee Hock School of Public Health National University Hospital National University Health System Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hersharan","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Nephrology National University Hospital National University Health System Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeline Ting Hui","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Nephrology National University Hospital National University Health System Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anantharaman","family":"Vathsala","sequence":"additional","affiliation":[{"name":"Department of Nephrology National University Hospital National University Health System Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Yee","family":"Tiong","sequence":"additional","affiliation":[{"name":"Department of Urology National University Hospital National University Health System Singapore 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