{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T05:26:45Z","timestamp":1767245205847,"version":"3.41.2"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T00:00:00Z","timestamp":1487548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Major <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> mismatch between donor and recipient in bone marrow transplantation (<jats:styled-content style=\"fixed-case\">BMT<\/jats:styled-content>) may cause hemolysis, delayed red blood cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) engraftment and pure red cell aplasia (<jats:styled-content style=\"fixed-case\">PRCA<\/jats:styled-content>), which result in increased transfusion needs. High pretransplant anti\u2010A\/B antibody titers have been associated with increased risk of <jats:styled-content style=\"fixed-case\">PRCA<\/jats:styled-content>. Herein, we studied the impact of anti\u2010A\/B titers on transfusion needs after <jats:styled-content style=\"fixed-case\">BMT<\/jats:styled-content> with major <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> mismatch.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the medical charts of 27 patients who underwent to <jats:styled-content style=\"fixed-case\">BMT<\/jats:styled-content> with major <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> mismatch and categorized them into two groups according to anti\u2010A\/B titers of IgG (\u226416 and \u226532). We recorded the number of <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> and platelet units transfused in the first 180\u00a0days after transplantation. We also evaluated the impact of anti\u2010A\/B titers on overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with anti\u2010A\/B titer \u226532 of IgG class required more <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> transfusion than patients with titer \u226416 (6.60\u00b14.55 vs 21.29\u00b114.68; <jats:italic>P<\/jats:italic>=.03). Anti\u2010A\/B of IgM class had no impact on both <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> and platelet transfusion needs. Anti\u2010A\/B titers had no impact on overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher titers of anti\u2010A\/B antibodies of IgG class, but not of IgM, are associated with a higher demand for <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> transfusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12913","type":"journal-article","created":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T04:01:39Z","timestamp":1486180899000},"source":"Crossref","is-referenced-by-count":8,"title":["Higher Anti\u2010A\/B isoagglutinin titers of IgG class, but not of IgM, are associated with increased red blood cell transfusion requirements in bone marrow transplantation with major <scp>ABO<\/scp>\u2010mismatch"],"prefix":"10.1111","volume":"31","author":[{"given":"Gil Cunha","family":"De Santis","sequence":"first","affiliation":[{"name":"Internal Medicine Center for Cell\u2010Based Therapy of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0873-1206","authenticated-orcid":false,"given":"Aline Cristina","family":"Garcia\u2010Silva","sequence":"additional","affiliation":[{"name":"Internal Medicine Center for Cell\u2010Based Therapy of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliana Martinelli","family":"Dotoli","sequence":"additional","affiliation":[{"name":"Internal Medicine Center for Cell\u2010Based Therapy of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela Tinti","family":"de Castro","sequence":"additional","affiliation":[{"name":"Internal Medicine Center for Cell\u2010Based Therapy of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda Pinto","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Internal Medicine Ribeir\u00e3o Preto School of Medicine University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimas Tadeu","family":"Covas","sequence":"additional","affiliation":[{"name":"Internal Medicine Ribeir\u00e3o Preto School of Medicine University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.135"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.01.084"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1985.tb00152.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00735.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-007-0304-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40050543.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.036"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13356"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03295.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12933"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01914.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702121"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:50:00Z","timestamp":1695513000000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,20]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/ctr.12913"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12913","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2017,2,20]]},"article-number":"e12913"}}