{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:05:03Z","timestamp":1779296703493,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Angiotensin\u2010converting enzyme inhibitors (ACEIs) and angiotensin II receptor type 1 blockers (ARBs) are often prescribed for renal transplant recipients (<jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>s), but the outcomes of these medications in <jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>s remain controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The PubMed, Embase, and Cochrane Library databases were systematically searched. Randomized controlled trials investigating the outcomes of ACEI\/ARBs in <jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>s were included for meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two trials with 2242 patients were identified. After treatment for at least 12\u00a0months, ACEI\/ARBs were associated with a decline in glomerular filtration rate (<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>) (weighed mean differences [<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content>] \u22125.76\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min; 95% confidence intervals [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: \u22129.31 to \u22122.20) and a decrease in hemoglobin (<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content> \u22129.81\u00a0g\/L; 95% CI: \u221214.98 to \u22124.64). There were no significant differences in mortality between <jats:styled-content style=\"fixed-case\">ACEI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">ACEI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content> groups (risk ratio [<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>] 0.98, 95% CI: 0.58 to 1.76), nor in graft failure (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.68, 95% CI: 0.38 to 1.32). After short\u2010term treatment (less than 1\u00a0year), significant differences were found in changes of 24\u2010hour proteinuria (<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content>\u22120.57\u00a0g\/d; 95% CI: \u22120.72 to \u22120.42) and serum potassium (<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content> 0.25\u00a0<jats:styled-content style=\"fixed-case\">mE<\/jats:styled-content>q\/L; 95% CI: 0.14 to 0.37) in <jats:styled-content style=\"fixed-case\">ACEI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content> groups compared to control arm, while these differences were not confirmed in the long run.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta\u2010analysis indicates <jats:styled-content style=\"fixed-case\">ACEI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content>s may be prescribed to <jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>s with <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> and hemoglobin being carefully monitored.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12917","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T12:07:02Z","timestamp":1486728422000},"source":"Crossref","is-referenced-by-count":6,"title":["Short\u2010 and long\u2010term outcomes with renin\u2013angiotensin\u2013aldosterone inhibitors in renal transplant recipients: A meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"31","author":[{"given":"Ruo\u2010xi","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Nephrology West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia\u2010fei","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Radiology West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010jiao","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Technology Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000070864"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.03.013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13384"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2009.44"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-2-200107170-00007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.04.077"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001999"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02834.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr276"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000244587.74768.f7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a9e960"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006050543"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(00)01249-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181bf13d9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.06.225"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200112150-00013"},{"key":"e_1_2_8_18_1","unstructured":"HigginsJPT GreenS.Cochrane handbook for systemic reviews of intervention. 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