{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T01:13:55Z","timestamp":1768353235664,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The management of corticosteroids refractory chronic graft versus host disease (<jats:styled-content style=\"fixed-case\">cGVHD<\/jats:styled-content>) remains controversial. Retrospective analysis of patients treated at the Integrated Center of Oncology by total nodal irradiation (<jats:styled-content style=\"fixed-case\">TNI<\/jats:styled-content>) was performed to evaluate its therapy potency. <jats:styled-content style=\"fixed-case\">TNI<\/jats:styled-content> delivers a dose of 1\u00a0Gy in a single session. The delimitation of the fields is clinical (upper limit: external auditory meatus; lower limit: mid\u2010femur). No pre\u2010therapeutic dosimetry scanner was necessary. Evaluation of the efficacy was by clinical measures at 6\u00a0months after the treatment. Twelve patients were treated by <jats:styled-content style=\"fixed-case\">TNI<\/jats:styled-content> between January 2010 and December 2013. <jats:styled-content style=\"fixed-case\">TNI<\/jats:styled-content> was used in second\u2010line treatment or beyond. The median time between allograft and <jats:styled-content style=\"fixed-case\">TNI<\/jats:styled-content> was 31.2\u00a0months, and the median time between the first manifestations of <jats:styled-content style=\"fixed-case\">cGVHD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TNI<\/jats:styled-content> was about 24.2\u00a0months. Of the 12 patients, nine had a clinical response at 6\u00a0months (75%), including five complete clinical responses (41.6%). Five patients could benefit from a reduction of corticosteroid doses. Three patients had hematologic toxicity. <jats:styled-content style=\"fixed-case\">TNI<\/jats:styled-content> could be considered as an option for the treatment of a cutaneous and\/or soft tissues corticosteroids refractory <jats:styled-content style=\"fixed-case\">cGVHD<\/jats:styled-content>. However, prospective randomized and double\u2010blind trials remain essential to answer the questions about <jats:styled-content style=\"fixed-case\">TNI<\/jats:styled-content> safety and effectiveness.<\/jats:p>","DOI":"10.1111\/ctr.12923","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T07:56:45Z","timestamp":1486627005000},"source":"Crossref","is-referenced-by-count":2,"title":["Treatment of cutaneous and\/or soft tissue manifestations of corticosteroids refractory chronic graft versus host disease (<scp>cGVHD<\/scp>) by a total nodal irradiation (TNI)"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2539-8655","authenticated-orcid":false,"given":"Guillaume","family":"Peyraga","sequence":"first","affiliation":[{"name":"Department of Radiotherapy Integrated Center of Oncology ICO Paul Papin  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thibaut","family":"Lizee","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Integrated Center of Oncology ICO Paul Papin  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Gustin","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Integrated Center of Oncology ICO Paul Papin  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Clement\u2010Colmou","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Integrated Center of Oncology ICO Ren\u00e9 Gauducheau  Saint\u2010Herblain France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Di Bartolo","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Integrated Center of Oncology ICO Paul Papin  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephane","family":"Supiot","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Integrated Center of Oncology ICO Ren\u00e9 Gauducheau  Saint\u2010Herblain France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc\u2010Andre","family":"Mahe","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Integrated Center of Oncology ICO Ren\u00e9 Gauducheau  Saint\u2010Herblain France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"Department of Blood Diseases University Hospital of Angers  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Mege","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Integrated Center of Oncology ICO Paul Papin  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"87","article-title":"Report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders","volume":"2010","author":"Pasquini MC","year":"2010","journal-title":"Clin Transpl"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"245","article-title":"Impact of chronic GVHD on late complications after hematopoietic cell transplantation","volume":"10","author":"Deeg HJ","year":"2005","journal-title":"Hematol Amst Neth"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.06.015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-11-465583"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2011.01264.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5045\/kjh.2011.46.3.153"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-141481"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32834ba87d"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.11.960"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-01-514752"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60237-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.4049\/jimmunol.132.2.1026","article-title":"Differential recovery of circulating T cell subsets after nodal irradiation for Hodgkin's disease","volume":"132","author":"Haas GS","year":"1984","journal-title":"J Immunol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.07.035"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400306"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00709.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000173436.99153.78"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.001"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.05.004"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.240"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v13i3.3767"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.12.009"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-8-92"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-015-0362-3"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.237"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.06.005"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2015.10.003"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-551994"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12923","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:48:55Z","timestamp":1695512935000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,14]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/ctr.12923"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12923","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,14]]},"article-number":"e12923"}}