{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:10:24Z","timestamp":1790946624460,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,11]],"date-time":"2017-03-11T00:00:00Z","timestamp":1489190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transversus abdominis plane (<jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content>) block provides effective postoperative analgesia after abdominal surgeries. It can be also a useful strategy to reduce perioperative opioid consumption, support intraoperative hemodynamic stability, and promote early recovery from anesthesia. The aim of this prospective randomized double\u2010blind study was to assess the effect of subcostal <jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content> blocks on perioperative opioid consumption, hemodynamic, and recovery time in living liver donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The prospective, double\u2010blinded, randomized controlled study was conducted with 49 living liver donors, aged 18\u201065\u00a0years, who were scheduled to undergo right hepatectomy. Patients who received subcostal <jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content> block in combination with general anesthesia were allocated into Group 1, and patients who received general anesthesia alone were allocated into Group 2. The <jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content> blocks were performed bilaterally by obtaining an image with real\u2010time ultrasound guidance using 0.5% bupivacaine diluted with saline to reach a total volume of 40\u00a0mL. The primary outcome measure in our study was perioperative remifentanil consumption. Secondary outcomes were mean blood pressure (<jats:styled-content style=\"fixed-case\">MBP<\/jats:styled-content>), heart rate (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>), mean desflurane requirement, anesthesia recovery time, frequency of emergency vasopressor use, total morphine use, and length of hospital stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total remifentanil consumption and the anesthesia recovery time were significantly lower in Group 1 compared with Group 2. Postoperative total morphine use and length of hospital stay were also reduced. Changes in the <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> were similar in the both groups. There were no significant differences in <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MBP<\/jats:styled-content> between groups at any time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combining subcostal <jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content> blocks with general anesthesia significantly reduced perioperative and postoperative opioid consumption, provided shorter anesthesia recovery time, and length of hospital stay in living liver donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12931","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T21:32:48Z","timestamp":1487194368000},"source":"Crossref","is-referenced-by-count":41,"title":["Effect of transversus abdominis plane block in combination with general anesthesia on perioperative opioid consumption, hemodynamics, and recovery in living liver donors: The prospective, double\u2010blinded, randomized study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3860-6919","authenticated-orcid":false,"given":"Mehmet A.","family":"Erdogan","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Reanimation School of Medicine Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulku","family":"Ozgul","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Reanimation School of Medicine Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muharrem","family":"U\u00e7ar","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Reanimation School of Medicine Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet R.","family":"Yalin","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Reanimation School of Medicine Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf Z.","family":"Colak","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Reanimation School of Medicine Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemil","family":"\u00c7olak","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics School of Medicine Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin I.","family":"Toprak","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Reanimation School of Medicine Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000066"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9185.150547"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.03104.x"},{"key":"e_1_2_8_5_1","first-page":"1241","article-title":"Transversus abdominis plane block in combination with general anesthesia provides better intraoperative hemodynamic control and quicker recovery than general anesthesia alone in high\u2010risk abdominal surgery patients","volume":"78","author":"Tsuchiya M","year":"2012","journal-title":"Minerva Anestesiol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep067"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e3181e66702"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.08.051"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27307"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.04.045"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-015-2085-x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(00)01592-X"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00115550-200511000-00003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1054\/jpai.2002.123652"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.707121"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000909"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182159bf8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjan.2013.10.014"},{"key":"e_1_2_8_19_1","first-page":"195","article-title":"Transversus abdominis plane\u00a0block\u00a0for analgesia after cesarean delivery. 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