{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:53:03Z","timestamp":1761630783035,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF\u20102011\u201002351876"],"award-info":[{"award-number":["RF\u20102011\u201002351876"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>TCF<\/jats:styled-content>7L2<\/jats:italic> rs7903146 C>T polymorphism is associated with diabetes in the general population but its independent impact on cardiovascular disease is debated. On this basis, we investigated its association with major adverse cardiac events (MACE<\/jats:styled-content>) in a single\u2010center cohort of non\u2010diabetic kidney transplant recipients (KTR<\/jats:styled-content>s).<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients with pretransplant diabetes were excluded and patients who developed post\u2010transplant diabetes were censored at time of diagnosis.<\/jats:p><\/jats:sec>Results<\/jats:title>rs7903146 C>T polymorphism appeared to modulate the risk of MACE<\/jats:styled-content>: 5\u2010year prevalence was 0.8% in CC<\/jats:styled-content> patients, 7.2% in CT<\/jats:styled-content> patients and 9.7% in TT<\/jats:styled-content> patients (P<\/jats:italic><.001). TCF<\/jats:styled-content>7L2 rs7903146 was an independent predictor of MACE<\/jats:styled-content> in a multivariate Cox regression model (for each T allele, HR<\/jats:styled-content>: 2.99, 95%CI<\/jats:styled-content>: 1.62\u20105.52, P<\/jats:italic><.001), together with history of cardiac ischemic events (HR<\/jats:styled-content>: 8.69, 95%CI<\/jats:styled-content>: 3.57\u201021.16, P<\/jats:italic><.001), DGF<\/jats:styled-content> (HR<\/jats:styled-content>: 2.42, 95%CI<\/jats:styled-content>: 0.98\u20105.95, P<\/jats:italic>=.056) and HLA<\/jats:styled-content>\u2010mismatches (for each mismatch: HR<\/jats:styled-content>: 1.55, 95%CI<\/jats:styled-content>: 1.00\u20102.43, P<\/jats:italic>=.053). Introduction of rs7903146 C>T polymorphism into a model based on these clinical variables significantly increased predictive power for MACE<\/jats:styled-content> (P<\/jats:italic>=.003).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>TCF<\/jats:styled-content>7L2 rs7903146 T allele may be strongly and independently associated with MACE<\/jats:styled-content> in non\u2010diabetic KTR<\/jats:styled-content>s.<\/jats:p>These findings suggest the possibility of employing this SNP<\/jats:styled-content> to more accurately stratify cardiological risk in KTR<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12959","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T08:02:47Z","timestamp":1489651367000},"source":"Crossref","is-referenced-by-count":5,"title":["Pilot cohort study on the potential role of TCF<\/scp>7L2<\/i> rs7903146 on ischemic heart disease among non\u2010diabetic kidney transplant recipients"],"prefix":"10.1111","volume":"31","author":[{"given":"Marco","family":"Quaglia","sequence":"first","affiliation":[{"name":"Department of Translational Medicine Nephrology and Kidney Transplant Unit University of Piemonte Orientale Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Musetti","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Nephrology and Kidney Transplant Unit University of Piemonte Orientale Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Merlotti","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Nephrology and Kidney Transplant Unit University of Piemonte Orientale Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando A.","family":"Genazzani","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco & Centro di Ricerca Interdipartimentale di Farmacogenetica e Farmacogenomica (CRIFF) University of Piemonte Orientale Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Cargnin","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco & Centro di Ricerca Interdipartimentale di Farmacogenetica e Farmacogenomica (CRIFF) University of Piemonte Orientale Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Cena","sequence":"additional","affiliation":[{"name":"Unit of Medical Statistics and Cancer Epidemiology University of Piemonte Orientale and CPO Piemonte Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Cantaluppi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Nephrology and Kidney Transplant Unit University of Piemonte Orientale Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Terrazzino","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco & Centro di Ricerca Interdipartimentale di Farmacogenetica e Farmacogenomica (CRIFF) University of Piemonte Orientale Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0108-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5527\/wjn.v3.i4.156"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2003.11.028"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/CRD.0000000000000044","article-title":"Pathophysiologic and treatment strategies for cardiovascular disease in end\u2010stage renal disease and kidney 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