{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:10:07Z","timestamp":1769105407252,"version":"3.49.0"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,16]],"date-time":"2017-04-16T00:00:00Z","timestamp":1492300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heart transplantation (<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>) should normalize cardiac endocrine function, but brain natriuretic peptide (<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>) levels remain elevated after <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>, even in the absence of left ventricular hemodynamic disturbance or allograft rejection. Right ventricle (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) abnormalities are common in <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> recipients (<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x), as a result of engraftment process, tricuspid insufficiency, and\/or repeated inflammation due to iterative endomyocardial biopsies. <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> function follow\u2010up is vital for patient management as <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> dysfunction is a recognized cause of in\u2010hospital death and is responsible for a worse prognosis. Interestingly, few and controversial data are available concerning the relationship between plasma <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> levels and <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> functional impairment in <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x. This suggests that infra\u2010clinical modifications, such as subtle immune system disorders or hypoxic conditions, might influence <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> expression. Nevertheless, due to other altered circulating molecular forms of <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>, a lack of specificity of <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> assays is described in heart failure patients. This phenomenon could exist in <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> population and could explain elevated <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> plasmatic levels despite a normal <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> function. In clinical practice, intra\u2010individual change in <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> over time, rather than absolute <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> values, might be more helpful in detecting right cardiac dysfunction in <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x.<\/jats:p>","DOI":"10.1111\/ctr.12969","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T20:36:36Z","timestamp":1489782996000},"source":"Crossref","is-referenced-by-count":12,"title":["Brain natriuretic peptide and right heart dysfunction after heart transplantation"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-2842","authenticated-orcid":false,"given":"Samy","family":"Talha","sequence":"first","affiliation":[{"name":"Department of Physiology and Functional Explorations H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"},{"name":"Equipe d'Accueil 3072 Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Charloux","sequence":"additional","affiliation":[{"name":"Department of Physiology and Functional Explorations H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"},{"name":"Equipe d'Accueil 3072 Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Piquard","sequence":"additional","affiliation":[{"name":"Equipe d'Accueil 3072 Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Geny","sequence":"additional","affiliation":[{"name":"Department of Physiology and Functional Explorations H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"},{"name":"Equipe d'Accueil 3072 Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2001.093"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000025242.79963.4C"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00452-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2004.06.002"},{"key":"e_1_2_9_6_1","first-page":"269","article-title":"Brain natriuretic peptide in pulmonary arterial hypertension: biomarker and potential therapeutic agent","volume":"29","author":"Casserly B","year":"2009","journal-title":"Drug Des Devel Ther"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft052"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00902.2002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00239.2012"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2008.00818.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.4.969"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00027.2002"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq331"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.76.4.819"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.976613"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.08.082"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02871-0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)00168-9"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(98)70297-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7133.2009.00055.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.3.287"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2003.10.012"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2003.08.005"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700011"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.01.008"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000263338.39555.21"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2005.10.007"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12710"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-015-3252-x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2004.00010.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.10.5"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.000513"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefro.2015.03.002"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2003.50118"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/27.2.188"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/27.12.2135"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(03)00190-6"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v6.i1.4"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.01.001"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e3181948b37"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)00083-9"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.05.038"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021087"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070629"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.63.1.207"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12767"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(95)00121-2"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3128"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.21.14926"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.143883"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001174"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.057638"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.153585"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508782102"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.063"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.790774"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.076141"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.113373"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407680-8.00001-4"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.106.081083"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12969","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:39:25Z","timestamp":1695551965000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,16]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/ctr.12969"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12969","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,16]]},"article-number":"e12969"}}