{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:46:50Z","timestamp":1793767610417,"version":"4.6.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Astellas Scientific","award":["NCT02221583"],"award-info":[{"award-number":["NCT02221583"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe obesity has been shown to limit access to renal transplantation in patients with end\u2010stage renal disease (<jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content>). Laparoscopic sleeve gastrectomy (<jats:styled-content style=\"fixed-case\">LSG<\/jats:styled-content>) has been performed in the<jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content>population to assist in achieving waitlist and transplant eligibility. Little is known about how<jats:styled-content style=\"fixed-case\">LSG<\/jats:styled-content>impacts the bioequivalence of tacrolimus products and immunosuppression pharmacokinetics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, open\u2010label, single\u2010dose, crossover, two\u2010period pharmacokinetic (<jats:styled-content style=\"fixed-case\">PK<\/jats:styled-content>) study. The purpose of this study was to assess single\u2010dose<jats:styled-content style=\"fixed-case\">PK<\/jats:styled-content>of immediate\u2010release tacrolimus (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>), extended\u2010release tacrolimus (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>), and mycophenolic acid (<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>) in adult<jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content>patients post\u2010<jats:styled-content style=\"fixed-case\">LSG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three subjects were included in the 24\u2010hour<jats:styled-content style=\"fixed-case\">PK<\/jats:styled-content>assessments. The ratio of geometric means between<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>was 103.5% (90% CI; 89.6%\u2010119.6%) for<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>0\u201024<\/jats:sub>and 92.5% (90% CI; 80.4%\u2010106.4%) for<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>.<jats:styled-content style=\"fixed-case\">PK<\/jats:styled-content>parameters were similar between<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>, except for<jats:italic>C<\/jats:italic><jats:sub>min<\/jats:sub>(<jats:italic>P<\/jats:italic>=.004) and<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>(<jats:italic>P<\/jats:italic>=.04).<jats:styled-content style=\"fixed-case\">MPA AUC<\/jats:styled-content><jats:sub>0\u201024<\/jats:sub>was similar when given with either<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>(<jats:italic>P<\/jats:italic>=.32). Patients expressing<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>3A5*1 genotypes had lower tacrolimus<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>0\u201024<\/jats:sub>values vs those with<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>3A5*3\/*3 (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content><jats:italic>P<\/jats:italic>&lt;.001;<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content><jats:italic>P<\/jats:italic>=.008). Genotype did not impact<jats:styled-content style=\"fixed-case\">MPA PK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dose modification of immunosuppressants post\u2010<jats:styled-content style=\"fixed-case\">LSG<\/jats:styled-content>may not be necessary aside from standard therapeutic drug monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12975","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T14:56:42Z","timestamp":1490453802000},"source":"Crossref","is-referenced-by-count":30,"title":["Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy"],"prefix":"10.1111","volume":"31","author":[{"given":"Tayyab S.","family":"Diwan","sequence":"first","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3804-6517","authenticated-orcid":false,"given":"Alicia B.","family":"Lichvar","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbie D.","family":"Leino","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A.","family":"Vinks","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Christians","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology iC42 Clinical Research and Development University of Colorado Denver Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele R.","family":"Shields","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Cincinnati College of Medicine Cincinnati OH USA"},{"name":"The Christ Hospital Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Cardi","sequence":"additional","affiliation":[{"name":"The Christ Hospital Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases Department of Internal Medicine University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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