{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:40:27Z","timestamp":1758631227564,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:00:00Z","timestamp":1501027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kidney transplant in patients with liver cirrhosis and nondialysis chronic kidney disease (CKD) is controversial. We report 14 liver cirrhotic patients who had persistently low MDRD\u20106 estimated glomerular filtration rate (e\u2010GFR) &lt;40\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> for \u22653\u00a0months and underwent either liver transplant alone (LTA; n=9) or simultaneous liver\u2010kidney transplant (SLKT; n=5). Pretransplant, patients with LTA compared with SLKT had lower serum creatinine (2.5\u00b10.73 vs 4.6\u00b10.52\u00a0mg\/dL, <jats:italic>P<\/jats:italic>=.001), higher MDRD\u20106 e\u2010GFR (21.0\u00b17.2 vs 10.3\u00b12.0\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>=.002), higher 24\u2010hour urine creatinine clearance (34.2\u00b18.8 vs 18.0\u00b12.2\u00a0mL\/min, <jats:italic>P<\/jats:italic>=.002), lower proteinuria (133.2\u00b1117.7 vs 663\u00b1268.2\u00a0mg\/24\u00a0h, <jats:italic>P<\/jats:italic>=.0002), and relatively normal kidney biopsy and ultrasound findings. Post\u2010LTA, the e\u2010GFR (mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>) increased in all nine patients, with mean e\u2010GFR at 1\u00a0month (49.8\u00b18.4), 3\u00a0months (49.6\u00b18.7), 6\u00a0months (49.8\u00b18.1), 12\u00a0months (47.6\u00b19.2), 24\u00a0months (47.9\u00b19.1), and 36\u00a0months (45.1\u00b17.3) significantly higher compared to pre\u2010LTA e\u2010GFR (<jats:italic>P<\/jats:italic>\u2264.005 at all time points). One patient developed end\u2010stage renal disease 9\u00a0years post\u2010LTA and another patient expired 7\u00a0years post\u2010LTA. The low e\u2010GFR alone in the absence of other markers or risk factors of CKD should not be an absolute criterion for SLKT in patients with liver cirrhosis.<\/jats:p>","DOI":"10.1111\/ctr.13008","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T15:36:47Z","timestamp":1494862607000},"source":"Crossref","is-referenced-by-count":3,"title":["Kidney outcomes in patients with liver cirrhosis and chronic kidney disease receiving an orthotopic liver transplant alone"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0141-3371","authenticated-orcid":false,"given":"Neeraj","family":"Singh","sequence":"first","affiliation":[{"name":"John C. McDonald Regional Transplant Center Willis Knighton Medical Center  Shreveport LA USA"},{"name":"Division of Nephrology Department of Medicine LSUHSC\u2010S  Shreveport LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahab","family":"Ahmadzadeh","sequence":"additional","affiliation":[{"name":"John C. McDonald Regional Transplant Center Willis Knighton Medical Center  Shreveport LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hosein","family":"Shokouh\u2010Amiri","sequence":"additional","affiliation":[{"name":"John C. McDonald Regional Transplant Center Willis Knighton Medical Center  Shreveport LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasir A.","family":"Qazi","sequence":"additional","affiliation":[{"name":"Division of Nephrology Keck School of Medicine University of Southern California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Sequeira","sequence":"additional","affiliation":[{"name":"John C. McDonald Regional Transplant Center Willis Knighton Medical Center  Shreveport LA USA"},{"name":"Division of Nephrology Department of Medicine LSUHSC\u2010S  Shreveport LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hrishikesh","family":"Samant","sequence":"additional","affiliation":[{"name":"John C. McDonald Regional Transplant Center Willis Knighton Medical Center  Shreveport LA USA"},{"name":"Division of Gastroenterology Department of Medicine LSUHSC\u2010S  Shreveport LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"McMillan","sequence":"additional","affiliation":[{"name":"John C. McDonald Regional Transplant Center Willis Knighton Medical Center  Shreveport LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gazi B.","family":"Zibari","sequence":"additional","affiliation":[{"name":"John C. McDonald Regional Transplant Center Willis Knighton Medical Center  Shreveport LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.09.018"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90031-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90441-6"},{"key":"e_1_2_8_5_1","first-page":"514","article-title":"Survival and prognostic factors of cirrhotic patients with ascites: a study of 134 outpatients","volume":"88","author":"Salerno F","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04177.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007040394"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01526.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04190.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-147"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-009-0012-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02416.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04176.x"},{"key":"e_1_2_8_14_1","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification","volume":"39","author":"National Kidney Foundation","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13844"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12257"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13631"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.13398"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09600912"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12479"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.11.025"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.02.018"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20994"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26704"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03443.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240527"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(01)99000-6"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02807.x"},{"key":"e_1_2_8_29_1","first-page":"15","article-title":"Neutrophil gelatinase associated lipocalin (NGAL) \u2013 a biomarker of renal dysfunction in patients with liver cirrhosis: do we have enough proof?","volume":"8","author":"Firu SG","year":"2015","journal-title":"J Med Life"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.025"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13790"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:03:18Z","timestamp":1695477798000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,26]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/ctr.13008"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13008","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2017,7,26]]},"article-number":"e13008"}}