{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:30:45Z","timestamp":1753878645204,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T00:00:00Z","timestamp":1498348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CF 2014\u20102016"],"award-info":[{"award-number":["CF 2014\u20102016"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","award":["KF2013\u2010 0011","PR2013\u20100022"],"award-info":[{"award-number":["KF2013\u2010 0011","PR2013\u20100022"]}],"id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C mismatch in unrelated donor's hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) has been associated with poor patient outcome. However, the impact of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C mismatch in the context of <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> combined with in vivo T\u2010cell depletion remains unclear. We therefore performed a single\u2010center, retrospective analysis of the clinical outcome on patients with hematological malignancies treated with allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, who underwent T\u2010cell depletion. The majority of the patients (n=276) received a <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1\u2010matched graft that were either also <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C matched (n=260), or patients with the permissive <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*03:03\/03:04 mismatch (n=16), while the remaining patients (n=95) received a <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C\u2010mismatched graft (excluding <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*03:03\/03:04 mismatches). We did not observe any significant differences between the <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C\u2010matched patients (including the permissive <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*03:03\/03:04 mismatch) and the <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C\u2010mismatched patients regarding cumulative proportion surviving, graft failure, relapse\u2010free survival, relapse, or acute graft\u2010versus\u2010host disease. Our data suggest that in the context of high dose T lymphocyte\u2010depleting agents, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C matching is not essential for patients with hematological malignancies.<\/jats:p>","DOI":"10.1111\/ctr.13012","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T16:03:45Z","timestamp":1494950625000},"source":"Crossref","is-referenced-by-count":0,"title":["No effect of <scp>HLA<\/scp>\u2010C mismatch after allogeneic hematopoietic stem cell transplantation with unrelated donors and T\u2010cell depletion in patients with hematological malignancies"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0440-6924","authenticated-orcid":false,"given":"Isabelle","family":"Magalhaes","sequence":"first","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Uhlin","sequence":"additional","affiliation":[{"name":"Division of Surgery, Department of Clinical Science Intervention and Technology Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Clinical Immunology and Transfusion Medicine Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Schaffer","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Transfusion Medicine Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Sundin","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Clinical Science Intervention and Technology Karolinska Institutet  Stockholm Sweden"},{"name":"Pediatric Blood Disorders Immunodeficiency and Stem Cell Transplantation Astrid Lindgren Children's Hospital Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Hauzenberger","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Transfusion Medicine Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Remberger","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"},{"name":"Center for Allogeneic Stem Cell Transplantation Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Mattsson","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"},{"name":"Center for Allogeneic Stem Cell Transplantation Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00216"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.09.012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.05.028"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810223391701"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.11.4200"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.04.010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2006.759_2.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70127-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.01.002"},{"key":"e_1_2_6_11_1","first-page":"1562","article-title":"The 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