{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:36:12Z","timestamp":1758630972516,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:00:00Z","timestamp":1498176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Stavanger University Hospital","award":["Educational grant"],"award-info":[{"award-number":["Educational grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neutrophil gelatinase\u2010associated lipocalin (<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content>), a protein with bacteriostatic functions rapidly excreted from stimulated or damaged epithelial cells, is elevated in acute and chronic kidney disease. A calcineurin dependent signaling pathway for fibroblast growth factor 23 (<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>23) has been revealed, but the effect of calcineurin inhibitors (<jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>s) on the levels of <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> and markers of mineral metabolism in long\u2010term kidney transplant patients has not been explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross\u2010sectional study, 39 patients who received a first kidney transplant more than 10\u00a0years ago were split into two groups based on whether (n=28) or not (n=11) they used <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>s. Only patients with well\u2010functioning grafts defined as an estimated glomerular filtration rate \u226545\u00a0mL\/min per 1.73\u00a0m<jats:sup>2<\/jats:sup> were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median levels of <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content>, intact parathyroid hormone (iPTH), and <jats:styled-content style=\"fixed-case\">iFGF<\/jats:styled-content>23 were significantly higher in <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content> users vs <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content> nonusers, 167.0 (134.0\u2010235.0) ng\/mL vs 105.0 (91.3\u2010117.0) ng\/mL, <jats:italic>P<\/jats:italic>&lt;.001, 13.8 (10.0\u201017.3)\u00a0pmol\/L vs 8.4 (6.4\u20109.9) pmol\/L, <jats:italic>P<\/jats:italic>=.003, and 81.6 (56.4\u2010116.5) pg\/mL vs 61.8 (43.3\u201072.1) pg\/mL, <jats:italic>P<\/jats:italic>=.04 respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The median levels of <jats:styled-content style=\"fixed-case\">iFGF<\/jats:styled-content>23 were higher in <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content> users compared to <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content> nonusers giving support to the notion of a <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content> induced <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>23 resistance in the parathyroid. The net result of <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>s side effects needs to be further explored.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13015","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T07:17:14Z","timestamp":1495178234000},"source":"Crossref","is-referenced-by-count":4,"title":["The impact of calcineurin inhibitors on neutrophil gelatinase\u2010associated lipocalin and fibroblast growth factor 23 in long\u2010term kidney transplant patients"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1359-0348","authenticated-orcid":false,"given":"Inger Hj\u00f8rdis","family":"Bleskestad","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Stavanger University Hospital  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga Strand","family":"Thorsen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Stavanger University Hospital  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grete","family":"Jonsson","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Stavanger University Hospital  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d8yvind","family":"Skadberg","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Stavanger University Hospital  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lasse Gunnar","family":"G\u00f8ransson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Stavanger University Hospital  Stavanger Norway"},{"name":"Department of Clinical Medicine (K1) University of Bergen  Bergen 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