{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:20:53Z","timestamp":1776115253789,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T00:00:00Z","timestamp":1498348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>) with liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>) is not uncommon. Impact of terlipressin infusion on <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>, hemodynamics, and plasma concentration of neutrophil gelatinase\u2010associated lipocalin (<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content>) was studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients (n=50) were randomized (<jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>02059460, <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>) into two equal groups: terlipressin vs Controls. Terlipressin (1\u20104\u00a0\u03bcg\/kg\/h) was administrated for 5\u00a0days. Intraoperative transesophageal Doppler for hemodynamic management. Renal functions, peak portal vein blood flow velocity (<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>), and hepatic artery resistive index (<jats:styled-content style=\"fixed-case\">HARI<\/jats:styled-content>) were recorded. Plasma <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">pNGAL<\/jats:styled-content>) was measured baseline, 2 and 24\u00a0hours postreperfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) was the main etiology. Age, sex, model of end\u2010stage liver disease (<jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>), and renal functions were comparable. Postoperative <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> incidence and <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> concentrations were comparable (<jats:italic>P<\/jats:italic>&gt;.05) between terlipressin and controls groups (44% vs 48% and 112.5\u00b19 vs 93.1\u00b18\u00a0ng\/mL), respectively, but intraoperative <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> in both groups increased significantly 2\u00a0hours postreperfusion (<jats:italic>P<\/jats:italic>&lt;.05). The three <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> readings were comparable (<jats:italic>P<\/jats:italic>&gt;.05) between <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> (n=23) and non\u2010<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> developers (n=27). Mean arterial blood pressure (<jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>) was maintained in both groups with less systemic vascular resistance (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>) fluctuations with terlipressin. Median norepinephrine consumption was lower in terlipressin vs controls (8 vs 12\u00a0mg; <jats:italic>P<\/jats:italic>=.04). The <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HARI<\/jats:styled-content> were not affected by terlipressin at any stage (<jats:italic>P<\/jats:italic>&gt;.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Postliver transplant <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> was not prevented by terlipressin use nor predicted by <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13019","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T16:15:07Z","timestamp":1496247307000},"source":"Crossref","is-referenced-by-count":16,"title":["Impact of terlipressin infusion during and after live donor liver transplantation on incidence of acute kidney injury and neutrophil gelatinase\u2010associated lipocalin serum levels: A randomized controlled trial"],"prefix":"10.1111","volume":"31","author":[{"given":"Mohamed A.","family":"Kandil","sequence":"first","affiliation":[{"name":"Department of Anaesthesia National Liver Institute Menoufia University  Shebeen El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid M.","family":"Abouelenain","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Anaesthesia Menoufia University  Shebeen El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-2312","authenticated-orcid":false,"given":"Ayman","family":"Alsebaey","sequence":"additional","affiliation":[{"name":"Department of Hepatology National Liver Institute Menoufia University  Shebeen El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanaa S.","family":"Rashed","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia National Liver Institute Menoufia University  Shebeen El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed H.","family":"Afifi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Anaesthesia Menoufia University  Shebeen El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia National Hepatology and Tropical Medicine Research Institute Ministry of Health  Shebeen El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled A.","family":"Yassen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia National Liver Institute Menoufia University  Shebeen El\u2010Kom 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