{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:30:52Z","timestamp":1760646652573,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T00:00:00Z","timestamp":1499212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The epidemiology of infection after liver transplantation for hilar cholangiocarcinoma has not been systematically investigated. In this study of 124 patients, 255 infections occurred in 105 patients during the median follow\u2010up of 4.2\u00a0years. The median time to first infection was 15.1\u00a0weeks (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 1.6\u201062.6). The most common sites were the abdomen, bloodstream, and musculoskeletal system. Risk factors for any post\u2010transplant infection were pre\u2010transplant <jats:styled-content style=\"fixed-case\">VRE<\/jats:styled-content> colonization (Hazard Ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>] 1.9, <jats:italic>P<\/jats:italic>=.002), living donor transplantation (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 6.6, <jats:italic>P<\/jats:italic>&lt;.001), longer cold ischemia time (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.05 per 10\u00a0minutes, <jats:italic>P<\/jats:italic>&lt;.001), donor <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> seropositivity (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2.2, <jats:italic>P<\/jats:italic>&lt;.001), hepatic artery thrombosis (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2.6, <jats:italic>P<\/jats:italic>=.005), biliary stricture (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 3.8, <jats:italic>P<\/jats:italic>=.002), intra\u2010abdominal fluid collection (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 4.2, <jats:italic>P<\/jats:italic>&lt;.001), and re\u2010operations within 1\u00a0month after transplantation (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.7, <jats:italic>P<\/jats:italic>=.020). Abdominal infections were independently associated with hemodialysis requirement within 1\u00a0month after transplantation (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 5.6, <jats:italic>P<\/jats:italic>=.006), hepatic artery thrombosis (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 3.3, <jats:italic>P<\/jats:italic>=.007), biliary stricture (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 5.2, <jats:italic>P<\/jats:italic>&lt;.001), and abdominal fluid collection (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 3.7, <jats:italic>P<\/jats:italic>=.0002). Bloodstream infections were independently associated with allograft ischemia (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 17.8, <jats:italic>P<\/jats:italic>&lt;.001), biliary stricture (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 6.5, <jats:italic>P<\/jats:italic>=.005), and recipient <jats:styled-content style=\"fixed-case\">VRE<\/jats:styled-content> colonization (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 4, <jats:italic>P<\/jats:italic>&lt;.001). Abdominal infections (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2.3, <jats:italic>P<\/jats:italic>=.02) and <jats:italic>Clostridium difficile<\/jats:italic> infections (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 4.6, <jats:italic>P<\/jats:italic>=.01) were independently associated with increased mortality.<\/jats:p>","DOI":"10.1111\/ctr.13023","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T08:22:47Z","timestamp":1496391767000},"source":"Crossref","is-referenced-by-count":6,"title":["Epidemiology, risk factors, and outcomes of infections in patients undergoing liver transplantation for hilar cholangiocarcinoma"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0249-4361","authenticated-orcid":false,"given":"Poornima","family":"Ramanan","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Mayo Clinic  Rochester MN USA"},{"name":"William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic  Rochester MN USA"},{"name":"Division of Clinical Microbiology Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan W.","family":"Cummins","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Mayo Clinic  Rochester MN USA"},{"name":"William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark P.","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Mayo Clinic  Rochester MN USA"},{"name":"William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie K.","family":"Heimbach","sequence":"additional","affiliation":[{"name":"William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic  Rochester MN USA"},{"name":"Division of Transplantation Surgery Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Dierkhising","sequence":"additional","affiliation":[{"name":"William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic  Rochester MN USA"},{"name":"Division of Biomedical Statistics and Informatics Department of Health Sciences Research Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter K.","family":"Kremers","sequence":"additional","affiliation":[{"name":"William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic  Rochester MN USA"},{"name":"Division of Biomedical Statistics and Informatics Department of Health Sciences Research Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles B.","family":"Rosen","sequence":"additional","affiliation":[{"name":"William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic  Rochester MN USA"},{"name":"Division of Transplantation Surgery Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Gores","sequence":"additional","affiliation":[{"name":"William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic  Rochester MN USA"},{"name":"Division of Gastroenterology and Hepatology Department of Medicine Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymund R.","family":"Razonable","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Mayo Clinic  Rochester MN USA"},{"name":"William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic  Rochester MN 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