{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:30:00Z","timestamp":1753878600740,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma GmbH Germany","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mammalian target of rapamycin inhibitors (<jats:styled-content style=\"fixed-case\">mToR<\/jats:styled-content>i) allow calcineurin inhibitor (<jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>) sparing therapy in renal transplant recipients with possible beneficial effects on the long\u2010term allograft function and cardiovascular risk. The influence of <jats:styled-content style=\"fixed-case\">mToR<\/jats:styled-content>i on glucose metabolism is still under discussion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective analysis, renal allograft recipients switched from a cyclosporine A (CsA) to an everolimus (<jats:styled-content style=\"fixed-case\">EVR<\/jats:styled-content>)\u2010based immunosuppression in the first year after transplantation were compared with patients on continued CsA treatment. At 6\u2010month intervals, the prevalence of impaired fasting glucose (<jats:styled-content style=\"fixed-case\">IFG<\/jats:styled-content>) and new onset of diabetes after transplantation (<jats:styled-content style=\"fixed-case\">NODAT<\/jats:styled-content>) were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 146 renal transplant recipients were included. The cumulative prevalence of <jats:styled-content style=\"fixed-case\">IFG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NODAT<\/jats:styled-content> 30\u2010months post\u2010transplantation was significantly lower in patients switched to an immunosuppression with <jats:styled-content style=\"fixed-case\">EVR<\/jats:styled-content> compared to patients on continued CsA treatment (10% vs 22%, <jats:italic>P<\/jats:italic>=.049). However, patients switched to <jats:styled-content style=\"fixed-case\">EVR<\/jats:styled-content> showed a higher incidence of acute cellular rejections in the first 12\u00a0months (23% vs 11%, <jats:italic>P<\/jats:italic>=.048).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">EVR<\/jats:styled-content>\u2010based immunosuppression was associated with a similar or even improved glycemic control and improved renal function. 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