{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:02:08Z","timestamp":1781200928671,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T00:00:00Z","timestamp":1499126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>De novo donor\u2010specific antibodies (dnDSA<\/jats:styled-content>) after renal transplant are associated with acute rejection (AR<\/jats:styled-content>) and graft loss, yet most recipients with dnDSA<\/jats:styled-content> have stable function and no AR<\/jats:styled-content>. We assessed whether the persistence of dnDSA<\/jats:styled-content> increased the risk of a detrimental outcome.<\/jats:p><\/jats:sec>Methods<\/jats:title>A single\u2010center review of renal transplant recipients monitored for dnDSA<\/jats:styled-content> at multiple time points post\u2010transplant. An Isolated dnDSA<\/jats:styled-content> was defined as one positive dnDSA<\/jats:styled-content> and no additional positive tests, whereas \u22652 positive dnDSA<\/jats:styled-content> was defined as persistent dnDSA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 708 recipients, 22% developed dnDSA<\/jats:styled-content>, of whom 64% had persistent dnDSA<\/jats:styled-content>. At median follow\u2010up of 35 (range 12\u201074) months, there were fewer episodes of AR<\/jats:styled-content> in the isolated dnDSA<\/jats:styled-content> vs the persistent dnDSA<\/jats:styled-content> group (2% vs 22%; P<\/jats:italic><.001,) and fewer graft losses with isolated dnDSA<\/jats:styled-content> vs persistent dnDSA<\/jats:styled-content> (0% vs 10%; P<\/jats:italic>=.03). Within the persistent dnDSA<\/jats:styled-content> group, recipients with dnDSA<\/jats:styled-content> \u226560% of time points, had more AR<\/jats:styled-content> (32% vs 16%, P<\/jats:italic>=.10) and more graft losses (21% vs 2%; P<\/jats:italic>=.003) than those with dnDSA<\/jats:styled-content><60%.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Persistence of dnDSA<\/jats:styled-content> resulted in more AR<\/jats:styled-content> and graft failure than a single positive value. Recipients with longer duration of dnDSA<\/jats:styled-content> persistence had an additional increased risk of AR<\/jats:styled-content> and graft failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13025","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T22:50:50Z","timestamp":1496703050000},"source":"Crossref","is-referenced-by-count":5,"title":["The detrimental impact of persistent vs an isolated occurrence of de novo donor\u2010specific antibodies on intermediate\u2010term renal transplant outcomes"],"prefix":"10.1111","volume":"31","author":[{"given":"Jennifer M.","family":"Loucks\u2010DeVos","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Kansas Hospital Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd N.","family":"Eagar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Osama","family":"Gaber","sequence":"additional","affiliation":[{"name":"Department of Surgery Houston Methodist Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir J.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Houston Methodist Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry D.","family":"Teeter","sequence":"additional","affiliation":[{"name":"Department of State Health Services Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Graviss","sequence":"additional","affiliation":[{"name":"Houston Methodist Research Institute Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0870-629X","authenticated-orcid":false,"given":"Richard J.","family":"Knight","sequence":"additional","affiliation":[{"name":"Department of Surgery Houston Methodist Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000438196.30790.66"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182139da1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000055833.65192.3B"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02577.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31827d62e3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.190"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182543950"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302506"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2011.02.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198401000-00030"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198408000-00007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90103-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02800.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01688.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12590"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000216"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2009.01428.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.07.320"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03584.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04013.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.09.032"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000699"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2015.06.002"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:47:44Z","timestamp":1695476864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,4]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/ctr.13025"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13025","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,4]]},"article-number":"e13025"}}