{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:22:12Z","timestamp":1760955732415,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008321","name":"Toshiba Medical Systems","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic lung allograft dysfunction (CLAD) reduces long\u2010term graft survival. It is important to distinguish CLAD subtypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS) as RAS has a worse prognosis and accurate subtyping could facilitate targeted treatments. However, the current diagnosis of CLAD subtypes is based on pulmonary function test (PFT) results that reflect global estimates of lung function; anatomical modeling based on computed tomography (CT) has the potential to provide detailed analysis of global and regional lung function. The purpose of this study is to evaluate the utility of CT\u2010based anatomical modeling for the identification of RAS. This retrospective study included 51 patients (CLAD: 17 BOS and 17 RAS, control: 17 No\u2010CLAD). CT data were assessed using a biomechanical model\u2010based platform (MORFEUS) to characterize changes in lung deformation between baseline and disease onset. Lung deformation demonstrated high sensitivity and specificity (&gt;80%) in differentiating RAS from BOS (<jats:italic>P<\/jats:italic>&lt;.0001) and No\u2010CLAD (<jats:italic>P<\/jats:italic>&lt;.0001). There were matching radiological reading and inward deformation abnormalities in 79% of lung sections in patients with RAS. Anatomical modeling is complementary to conventional assessment in the diagnosis of RAS and potentially provides quantitative data that can help in the characterization and detailed assessment of heterogeneous lung parenchymal disease.<\/jats:p>","DOI":"10.1111\/ctr.13027","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T16:40:39Z","timestamp":1498668039000},"source":"Crossref","is-referenced-by-count":5,"title":["The role of biomechanical anatomical modeling via computed tomography for identification of restrictive allograft syndrome"],"prefix":"10.1111","volume":"31","author":[{"given":"Miho","family":"Horie","sequence":"first","affiliation":[{"name":"Joint Department of Medical Imaging University Health Network University of Toronto  Toronto ON Canada"},{"name":"Institute for Biomaterials and Biomedical Engineering University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohito","family":"Saito","sequence":"additional","affiliation":[{"name":"Latner Thoracic Surgery Research Laboratories Toronto General Research Institute University Health Network University of Toronto  Toronto ON Canada"},{"name":"Toronto Lung Transplant Program University Health Network University of Toronto  ON Canada"},{"name":"Department of Thoracic Surgery Kansai Medical University  Hirakara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Moseley","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Center University Health Network University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigia","family":"D'Errico","sequence":"additional","affiliation":[{"name":"Joint Department of Medical Imaging University Health Network University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Salazar","sequence":"additional","affiliation":[{"name":"Vital Images  Minnetonka MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9761-2825","authenticated-orcid":false,"given":"Daisuke","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Latner Thoracic Surgery Research Laboratories Toronto General Research Institute University Health Network University of Toronto  Toronto ON Canada"},{"name":"Toronto Lung Transplant Program University Health Network University of Toronto  ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristy","family":"Brock","sequence":"additional","affiliation":[{"name":"Department of Imaging Physics The University of Texas M.D. Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Yasufuku","sequence":"additional","affiliation":[{"name":"Latner Thoracic Surgery Research Laboratories Toronto General Research Institute University Health Network University of Toronto  Toronto ON Canada"},{"name":"Toronto Lung Transplant Program University Health Network University of Toronto  ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Binnie","sequence":"additional","affiliation":[{"name":"Latner Thoracic Surgery Research Laboratories Toronto General Research Institute University Health Network University of Toronto  Toronto ON Canada"},{"name":"Toronto Lung Transplant Program University Health Network University of Toronto  ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaf","family":"Keshavjee","sequence":"additional","affiliation":[{"name":"Institute for Biomaterials and Biomedical Engineering University of Toronto  Toronto ON Canada"},{"name":"Latner Thoracic Surgery Research Laboratories Toronto General Research Institute University Health Network University of Toronto  Toronto ON Canada"},{"name":"Toronto Lung Transplant Program University Health Network University of Toronto  ON Canada"},{"name":"Department of Thoracic Surgery Kansai Medical University  Hirakara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3227-8229","authenticated-orcid":false,"given":"Narinder","family":"Paul","sequence":"additional","affiliation":[{"name":"Joint Department of Medical Imaging University Health Network University of Toronto  Toronto ON Canada"},{"name":"Institute for Biomaterials and Biomedical Engineering University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.09.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.026"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.01.712"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005382-200304000-00003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12718"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12492"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2312030563"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.01.1054"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.07.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.01.1029"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1164\/rccm.201306-1155OC","article-title":"Impact of forced vital capacity loss on survival after the onset of chronic lung allograft dysfunction","volume":"15","author":"Todd JL","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.06.031"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/53\/1\/022"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JMI.1.2.024003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JMI.2.3.034501"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.06.014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201411-2105LE"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3685589"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2008.03.007"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.03.022"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1915012"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3676185"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.181.6.1811539"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-1292"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1214\/08-AOAS169"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13945"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.171"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13876"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.05.001"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.01.056"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2007.03.009"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13027","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:48:20Z","timestamp":1695476900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,25]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/ctr.13027"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13027","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2017,7,25]]},"article-number":"e13027"}}