{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:37:58Z","timestamp":1790206678524,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T00:00:00Z","timestamp":1503187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aging of the on\u2010dialysis population raises the issue of whether to propose elderly patients for kidney transplantation and how to manage their immunosuppression. This study aimed to analyze the outcome of kidney transplantation on an Italian series of elderly recipients. We included in this retrospective study all patients over 60\u00a0years, receiving a deceased\u2010donor kidney transplantation from January 2004 to December 2014 in two north Italian Centers. We analyzed the correlation of recipient age with graft's and patient's survival, delayed graft function, acute cellular rejection (<jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content>), surgical complications, infections, and glomerular filtration rate. Four hundred and fifty\u2010two patients with a median age of 65\u00a0years were included in the study. One\u2010, 3\u2010, and 5\u2010year patient's and graft's survival were, respectively, of 98.7%, 93%, 89% and 94.4%, 87.9%, 81.4%. The increasing recipient age was an independent risk factor only for the patient's (<jats:italic>P<\/jats:italic>=.008) and graft's survival (<jats:italic>P<\/jats:italic>=.002). <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content> and neoplasia were also associated to a worse graft survival. The reduced graft survival in elderly kidney recipients seems to be related more to the increasing recipient's age than to the donor's features. In this population, the optimization of organ allocation and immunosuppression may be the key factors to endorse improvements.<\/jats:p>","DOI":"10.1111\/ctr.13036","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T15:42:44Z","timestamp":1498146164000},"source":"Crossref","is-referenced-by-count":32,"title":["How does age affect the outcome of kidney transplantation in elderly recipients?"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2677-8967","authenticated-orcid":false,"given":"Flavia","family":"Neri","sequence":"first","affiliation":[{"name":"Kidney and Pancreas Transplant Unit Department of Surgery, Oncology and Gastroenterology Padua University Hospital  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrezia","family":"Furian","sequence":"additional","affiliation":[{"name":"Kidney and Pancreas Transplant Unit Department of Surgery, Oncology and Gastroenterology Padua University Hospital  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cavallin","sequence":"additional","affiliation":[{"name":"Esophageal and Digestive Tract Surgical Unit Veneto Institute of Oncology IOV IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5862-6151","authenticated-orcid":false,"given":"Matteo","family":"Ravaioli","sequence":"additional","affiliation":[{"name":"General Surgery and Transplant Unit Department of Medical and Surgical Sciences S. Orsola\u2010Malpighi Hospital University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Kidney and Pancreas Transplant Unit Department of Surgery, Oncology and Gastroenterology Padua University Hospital  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Donato","sequence":"additional","affiliation":[{"name":"Kidney and Pancreas Transplant Unit Department of Surgery, Oncology and Gastroenterology Padua University Hospital  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5473-8551","authenticated-orcid":false,"given":"Gaetano","family":"La Manna","sequence":"additional","affiliation":[{"name":"Nephrology Dialysis and Renal Transplant Unit S. Orsola\u2010Malpighi Hospital University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Daniele","family":"Pinna","sequence":"additional","affiliation":[{"name":"General Surgery and Transplant Unit Department of Medical and Surgical Sciences S. 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