{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:47:33Z","timestamp":1793656053868,"version":"4.5.1"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:00:00Z","timestamp":1500508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Better risk assessment tools are needed to predict post\u2010transplantation diabetes mellitus (<jats:styled-content style=\"fixed-case\">PTDM<\/jats:styled-content>). Using analytic morphomic measurements from computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) scans, we aimed to identify specific measures of body composition associated with <jats:styled-content style=\"fixed-case\">PTDM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed 99 non\u2010diabetic kidney transplant recipients who received pre\u2010transplant <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scans at a single institution between 1\/2005 and 5\/2014. Analytic morphomic techniques were used to measure abdominal adiposity, abdominal size, and psoas muscle area and density, standardized by gender. We measured the associations of these morphomic factors with <jats:styled-content style=\"fixed-case\">PTDM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010year incidence of <jats:styled-content style=\"fixed-case\">PTDM<\/jats:styled-content> was 18%. The morphomic factors significantly associated with <jats:styled-content style=\"fixed-case\">PTDM<\/jats:styled-content> included visceral fat area (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=1.84 per standard deviation increase, <jats:italic>P<\/jats:italic>=.020), body depth (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=1.79, <jats:italic>P<\/jats:italic>=.035), and total body area (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=1.67, <jats:italic>P<\/jats:italic>=.049). Clinical factors significantly associated with <jats:styled-content style=\"fixed-case\">PTDM<\/jats:styled-content> included African American race (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=3.01, <jats:italic>P<\/jats:italic>=.044), hypertension (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=2.97, <jats:italic>P<\/jats:italic>=.041), and dialysis vintage (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=1.24 per year on dialysis, <jats:italic>P<\/jats:italic>=.048). Body mass index was not associated with <jats:styled-content style=\"fixed-case\">PTDM<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=1.05, <jats:italic>P<\/jats:italic>=.188). On multivariate modeling, visceral fat area was an independent predictor of <jats:styled-content style=\"fixed-case\">PTDM<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=1.91, <jats:italic>P<\/jats:italic>=.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Analytic morphomics can identify pre\u2010transplant measurements of body composition that are predictive of <jats:styled-content style=\"fixed-case\">PTDM<\/jats:styled-content> in kidney transplant recipients. Pre\u2010transplant imaging contains a wealth of underutilized data that may inform <jats:styled-content style=\"fixed-case\">PTDM<\/jats:styled-content> prevention strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13040","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T15:48:38Z","timestamp":1498146518000},"source":"Crossref","is-referenced-by-count":28,"title":["Using analytic morphomics to describe body composition associated with post\u2010kidney transplantation diabetes mellitus"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9488-6847","authenticated-orcid":false,"given":"David C.","family":"Cron","sequence":"first","affiliation":[{"name":"Department of Surgery University of Michigan Medical School  Ann Arbor MI USA"},{"name":"Morphomic Analysis Group University of Michigan Medical School  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly A.","family":"Noon","sequence":"additional","affiliation":[{"name":"Department of Surgery Case Western Reserve University and University Hospitals Case Medical Center  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devan R.","family":"Cote","sequence":"additional","affiliation":[{"name":"Department of Surgery Case Western Reserve University and University Hospitals Case Medical Center  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7199-807X","authenticated-orcid":false,"given":"Michael N.","family":"Terjimanian","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Michigan Medical School  Ann Arbor MI USA"},{"name":"Morphomic Analysis Group University of Michigan Medical School  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J.","family":"Augustine","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Case Western Reserve University and University Hospitals Case Medical Center  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Michigan Medical School  Ann Arbor MI USA"},{"name":"Morphomic Analysis Group University of Michigan Medical School  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Englesbe","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Michigan Medical School  Ann Arbor MI USA"},{"name":"Morphomic Analysis Group University of Michigan Medical School  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7495-3758","authenticated-orcid":false,"given":"Kenneth J.","family":"Woodside","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Michigan Medical School  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12850"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31816b16bd"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318203c25f"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.3.583"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000250756.66348.9a"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000259617.21741.95"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00010.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004070580"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0340-5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1378"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31826028b1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aap.2013.08.020"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2010.03.039"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.10.111"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.07.042"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2001.21693"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12537"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.081778"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(91)90265-B"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(02)01003-1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.5.1212"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.06.029"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12606"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.892067"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533615569888"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001250"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:03:41Z","timestamp":1695477821000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,20]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/ctr.13040"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13040","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,20]]},"article-number":"e13040"}}