{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:30:01Z","timestamp":1753878601510,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,19]],"date-time":"2017-08-19T00:00:00Z","timestamp":1503100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This is an 18\u2010month prospective, randomized controlled trial (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>) designed to compare the effect of early conversion from cyclosporin to everolimus\/mycophenolic acid (E\u2010<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>) between 3 and 4\u00a0months post\u2010transplant to cyclosporin\/mycophenolic acid (CsA\u2010<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>) on left ventricular mass index (<jats:styled-content style=\"fixed-case\">LVMI<\/jats:styled-content>) at 3 and 18\u00a0months post\u2010transplant (primary outcome). Secondary outcomes included estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>), viral infection, and adverse events. Twenty\u2010four patients were randomized in a 1:1 ratio to E\u2010<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content> or CsA\u2010<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content> groups. There were no significant differences in mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">LVMI<\/jats:styled-content> at 3 (51.6\u00b118.5 vs 53.7\u00b115.7\u00a0g\/m<jats:sup>2.7<\/jats:sup>) and 18\u00a0months (52.7\u00b116.3 vs 51.7\u00b116.8\u00a0g\/m<jats:sup>2.7<\/jats:sup>) between CsA\u2010<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content> and E\u2010<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content> groups. The incidence of viral infections was reduced in E\u2010<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content> compared to CsA\u2010<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content> treatment groups (8% vs 50%, <jats:italic>P<\/jats:italic>=.02), but the incidences of acute rejection, adverse events, and drug discontinuation were similar between groups. There was an overall increase in <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> with time (0.04 log\u2010 mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> per 6\u00a0months, <jats:italic>P<\/jats:italic>=.012) but no significant difference between the two groups across time (0.11 log\u2010 mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>=.311). Immunosuppressive regimen comprising early conversion from cyclosporine to everolimus was not associated with a regression of <jats:styled-content style=\"fixed-case\">LVMI<\/jats:styled-content>, but a lower risk of viral infections was observed.<\/jats:p>","DOI":"10.1111\/ctr.13043","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T18:56:44Z","timestamp":1498762604000},"source":"Crossref","is-referenced-by-count":2,"title":["Impact of early conversion from cyclosporin to everolimus on left ventricular mass index: A randomized controlled trial"],"prefix":"10.1111","volume":"31","author":[{"given":"Anoushka","family":"Krishnan","sequence":"first","affiliation":[{"name":"Department of Renal Medicine Sir Charles Gairdner Hospital  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Teixeira\u2010Pinto","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health University of Sydney  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