{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:12:19Z","timestamp":1782601939607,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Diagnostics and Public Health","award":["FUR 2014 MB and PRIHTA 2014-453"],"award-info":[{"award-number":["FUR 2014 MB and PRIHTA 2014-453"]}]},{"name":"Transplant Kidney Center","award":["PRIHTA 2014-453"],"award-info":[{"award-number":["PRIHTA 2014-453"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prevention of transmission of malignancy from donors to recipients is an aim of donor assessment. We report the most stringent interpretation of the Italian National Guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A two\u2010step <jats:styled-content style=\"fixed-case\">ALERT<\/jats:styled-content> process was used: <jats:styled-content style=\"fixed-case\">ALERT<\/jats:styled-content>1 consisting of clinical, radiological, and laboratory tests; <jats:styled-content style=\"fixed-case\">ALERT<\/jats:styled-content>2, consisting of intraoperative assessment in suspicious lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred of 506 potential deceased donors entered the <jats:styled-content style=\"fixed-case\">ALERT<\/jats:styled-content> system. Forty\u2010one of 400 (10%) donors were excluded due to unacceptable risk of transmission. Of the remaining 359\u00a0193 required histopathology, which excluded malignancy or determined acceptable risk in 161\/193 (83%). Thirty\u2010five malignancies were identified: 19 (54%) at <jats:styled-content style=\"fixed-case\">ALERT<\/jats:styled-content>1, four (11%) at <jats:styled-content style=\"fixed-case\">ALERT<\/jats:styled-content>2, nine (26%) picked up at <jats:styled-content style=\"fixed-case\">ALERT<\/jats:styled-content>1 and confirmed by <jats:styled-content style=\"fixed-case\">ALERT<\/jats:styled-content>2. Three (9%) were missed by <jats:styled-content style=\"fixed-case\">ALERT<\/jats:styled-content> and diagnosed at postmortem examination. Prostate (n=12%, 34%) and renal cell (n=7%, 20%) were the most frequent carcinomas. The majority (92%) of prostate adenocarcinomas were of low risk and donation proceeded compared to 43% of renal carcinomas. Four renal carcinomas, two breast carcinomas, and a single case of nine different malignancies excluded donation.<\/jats:p><jats:p>Positive <jats:styled-content style=\"fixed-case\">ALERT<\/jats:styled-content> donors had statistically more malignant reports than negative <jats:styled-content style=\"fixed-case\">ALERT<\/jats:styled-content> donors (<jats:italic>P<\/jats:italic>=&lt;.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Histopathology is an essential component of the multidisciplinary assessment of donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13045","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T15:12:39Z","timestamp":1498835559000},"source":"Crossref","is-referenced-by-count":16,"title":["Rapid screening for malignancy in organ donors: 15\u2010year experience with the Verona \u201cAlert\u201d protocol and review of the literature"],"prefix":"10.1111","volume":"31","author":[{"given":"Albino","family":"Eccher","sequence":"first","affiliation":[{"name":"Pathology Unit Department of Diagnostics and Public Health University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-5843","authenticated-orcid":false,"given":"Luca","family":"Cima","sequence":"additional","affiliation":[{"name":"Pathology Unit Department of Diagnostics and Public Health University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ciangherotti","sequence":"additional","affiliation":[{"name":"Department of Surgical Science General and Hepatobiliary Surgery University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Montin","sequence":"additional","affiliation":[{"name":"Liver Transplant Unit 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