{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:02:12Z","timestamp":1778817732088,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) tend to experience both thrombotic and hemorrhagic complications; however, the pathophysiology remains unclear. This study aimed to identify the underlying mechanisms and characteristics of hemostatic problems in patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> and to demonstrate the role of kidney transplantation (<jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>) in correcting these hemostatic abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective observational study, 557 <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> recipients who did not receive perioperative plasmapheresis and who did not exhibit graft failure within 1\u00a0month after <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> recipients demonstrated increased levels of homocysteine and D\u2010dimer. A total of 80.9% of patients exhibited \u22651 thrombophilic factor at pre\u2010transplantation, and the proportion of these patients decreased to 47% at 28<jats:sup>th<\/jats:sup> post\u2010operative day (<jats:italic>P<\/jats:italic>&lt;.001). The renal function of patients with no thrombophilic factors was better than that of patients with \u22651 thrombophilic factor at all post\u2010operative assessments (<jats:italic>P<\/jats:italic>&lt;.001). The duration of pre\u2010operative dialysis significantly correlated with the thrombotic tendency of patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> before and after <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> can exhibit hypercoagulability, which might be caused by reduced renal function per se. Both <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> can aggravate the prothrombotic tendency of patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> via different mechanisms. Most thrombophilic factors in patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> were corrected after <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13051","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T15:28:52Z","timestamp":1499268532000},"source":"Crossref","is-referenced-by-count":10,"title":["Coagulation profile in patients with chronic kidney disease before and after kidney transplantation: A retrospective cohort study"],"prefix":"10.1111","volume":"31","author":[{"given":"Jinbeom","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Surgery College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang Woong","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Surgery College of Medicine The Catholic University of Korea  Seoul 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