{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T15:42:42Z","timestamp":1774712562353,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine the impact of lung transplantation on gastric motility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult recipients at a large, single center, who were retrospectively evaluated with solid gastric emptying (<jats:styled-content style=\"fixed-case\">SGE<\/jats:styled-content>) study post\u2010lung transplantation, but had no history of gastrointestinal intervention (ie, pyloroplasty or fundoplication), were selected between June 2005 and August 2013. Multivariable logistic regression was performed to determine risk factors associated with delayed gastric emptying (<jats:styled-content style=\"fixed-case\">DGE<\/jats:styled-content>) after transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Delayed gastric emptying (<jats:styled-content style=\"fixed-case\">DGE<\/jats:styled-content>) was noted in 236 patients (57%) after transplantation. On multivariable logistic regression, an underlining diagnosis of cystic fibrosis (<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>)\/bronchiectasis (adjusted odds ratio [<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>] 3.26, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.01) was a significant risk factor in predicting <jats:styled-content style=\"fixed-case\">DGE<\/jats:styled-content> after lung transplantation. There was no survival difference between patients with postoperative <jats:styled-content style=\"fixed-case\">DGE<\/jats:styled-content> vs those without (log\u2010rank test <jats:italic>P\u00a0<\/jats:italic>=\u00a0.53).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Delayed gastric emptying is very common following lung transplantation, occurring in over half of all lung transplant recipients with increased prevalence in patients with <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>. The association with cystic fibrosis could be secondary to extra\u2010pulmonary manifestations of the underlying disease or indicative of increased intraoperative vagal nerve injury. We speculate that <jats:styled-content style=\"fixed-case\">DGE<\/jats:styled-content> may play a substantial role in the increased reflux\u2010induced allograft injury seen after lung transplantation. Further prospective studies are needed to validate this hypothesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13065","type":"journal-article","created":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T08:28:47Z","timestamp":1501489727000},"source":"Crossref","is-referenced-by-count":19,"title":["Lung transplantation delays gastric motility in patients without prior gastrointestinal surgery\u2014A single\u2010center experience of 412 consecutive patients"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5032-675X","authenticated-orcid":false,"given":"Sameer A.","family":"Hirji","sequence":"first","affiliation":[{"name":"Department of Surgery Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian C.","family":"Gulack","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University Medical Center  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian R.","family":"Englum","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University Medical Center  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Speicher","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University Medical Center  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asvin M.","family":"Ganapathi","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University Medical Center  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asishana A.","family":"Osho","sequence":"additional","affiliation":[{"name":"Department of Surgery Massachusetts General Hospital  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul A.","family":"Shimpi","sequence":"additional","affiliation":[{"name":"Department of 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