{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:33:39Z","timestamp":1784302419210,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP15K15472"],"award-info":[{"award-number":["JP15K15472"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16H05465"],"award-info":[{"award-number":["JP16H05465"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Abstract<\/jats:title>The effectiveness of desensitization with rituximab in ABO<\/jats:styled-content>\u2010incompatible renal transplantation (ABO<\/jats:styled-content>\u2010I) has been widely reported. However, ABO<\/jats:styled-content>\u2010I outcomes are still worse than those of ABO<\/jats:styled-content>\u2010identical or ABO<\/jats:styled-content>\u2010compatible renal transplantation (ABO<\/jats:styled-content>\u2010Id\/C). We retrospectively examined the outcomes in consecutive living donor ABO<\/jats:styled-content>\u2010Id\/C (n\u00a0=\u00a0412) and ABO<\/jats:styled-content>\u2010I (n\u00a0=\u00a0205) cases to elucidate the causes of inferiority in ABO<\/jats:styled-content>\u2010I. ABO<\/jats:styled-content>\u2010I cases included recipients treated with rituximab (RIT<\/jats:styled-content>, n\u00a0=\u00a0131), splenectomy (SPX<\/jats:styled-content>, n\u00a0=\u00a021), or neither because of low anti\u2010A\/B antibody titers (NoR\/S, n\u00a0=\u00a053). Graft survival, infection, and de\u00a0novo HLA<\/jats:styled-content> antibody production were compared for ABO<\/jats:styled-content>\u2010I and ABO<\/jats:styled-content>\u2010Id\/C, followed by stratification into RIT<\/jats:styled-content> and NoR\/S groups. Propensity score\u2010based methods were employed to limit selection bias and potential confounders. Overall graft survival for ABO<\/jats:styled-content>\u2010I was significantly lower than that for ABO<\/jats:styled-content>\u2010Id\/C (92.8% vs 97.2% after 5\u00a0years, P<\/jats:italic>\u00a0=\u00a0.0037). Graft loss due to infection with ABO<\/jats:styled-content>\u2010I was significantly more frequent than that with ABO<\/jats:styled-content>\u2010Id\/C, whereas acute antibody\u2010mediated rejection (AMR<\/jats:styled-content>) caused no graft failure in ABO<\/jats:styled-content>\u2010I recipients. Stratified analysis demonstrated significantly higher infection risk with RIT<\/jats:styled-content> than with NoR\/S. Safe reduction or avoidance of rituximab in desensitization protocols might contribute to further improvement of ABO<\/jats:styled-content>\u2010I outcome.<\/jats:p>","DOI":"10.1111\/ctr.13071","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T13:12:38Z","timestamp":1502284358000},"source":"Crossref","is-referenced-by-count":22,"title":["Favorable results in ABO<\/scp>\u2010incompatible renal transplantation without B cell\u2010targeted therapy: Advantages and disadvantages of rituximab pretreatment"],"prefix":"10.1111","volume":"31","author":[{"given":"Manabu","family":"Okada","sequence":"first","affiliation":[{"name":"Department of Transplant and Endocrine Surgery Nagoya Daini Red Cross Hospital Nagoya Japan"},{"name":"Department of Renal Transplant Surgery Aichi Medical University School of Medicine Nagakute 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunji","family":"Narumi","sequence":"additional","affiliation":[{"name":"Department of Transplant and Endocrine Surgery Nagoya Daini Red Cross Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asami","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nagoya Daini Red Cross Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Morozumi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Masuko Memorial Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuharu","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Renal Transplant Surgery Aichi Medical University School of Medicine Nagakute Japan"},{"name":"Department of Kidney Disease and Transplant Immunology Aichi Medical University School of Medicine 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