{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:22:17Z","timestamp":1773098537849,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Kidney transplantation facilitates pregnancy in women with end\u2010stage kidney disease; however, the impact of pregnancy on short and longer\u2010term graft function is uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Obstetric, fetal, and graft outcomes for pregnancies from a large Australian transplant unit (1976\u20102015) were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 56 pregnancies in 35 women with mean age at conception 30.4\u00a0\u00b1\u00a00.6\u00a0years and mean transplant\u2010pregnancy interval 5.5\u00a0\u00b1\u00a00.5\u00a0years. The live birth rate was 78.9%. Preterm birth (&lt;37\u00a0weeks) occurred in 56.5%. Hypertensive disorders affected 76% of women (pre\u2010eclampsia in 30%). Median prepregnancy serum creatinine (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>r) was 100\u00a0\u03bcmol\/L (interquartile range (IQR), 80, 114\u00a0\u03bcmol\/L). One\u2010third had deterioration in graft dysfunction during pregnancy; of these, 63.2% did not return to baseline. At 2\u00a0years post\u2010partum, median SCr was 96.4\u00a0\u03bcmol\/L (IQR, 81.5\u2010124.3). Women with prepregnancy <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>r\u00a0&gt;\u00a0110\u00a0\u03bcmol\/L had increased risk of pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.4; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.2\u201016.8; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03), but not preterm birth (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.4; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.5\u201053; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04) or low birth\u2010weight babies (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.2; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.5\u20102.9; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). Women with <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>r\u00a0&gt;\u00a0140\u00a0\u03bcmol\/L preconception had worst <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>r trajectory, including higher rates of graft loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Kidney transplantation pregnancies remain at high risk of obstetric complications, particularly pre\u2010eclampsia. Prepregnancy graft function can be used to predict risk of adverse pregnancy outcomes and deterioration in graft function during and after delivery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13089","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T09:52:36Z","timestamp":1502704356000},"source":"Crossref","is-referenced-by-count":45,"title":["Pregnancy outcomes and impact of pregnancy on graft function in women after kidney transplantation"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3977-0382","authenticated-orcid":false,"given":"F.A.","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Central and Northern Adelaide Renal and Transplantation Services (CNARTS)  Adelaide SA Australia"},{"name":"Department of Medicine University of Adelaide  Adelaide SA 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