{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:27:26Z","timestamp":1753878446388,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The demand for kidney retransplantation following graft failure is rising. Repeat transplantation is often associated with poorer outcomes due to both immunological and surgical challenges. The aim of this study was to compare surgical and functional outcomes of kidney retransplantation in recipients that had previously had at least two kidney transplants with a focus on those with antibody incompatibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 66 patients who underwent renal transplantation at a single center between 2003 and 2011. Consecutive patients receiving their 3rd or 4th kidney were case\u2010matched with an equal number of 1st and 2nd transplants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two 3rd and 4th kidney transplants were matched with 22 first and 22\u00a0seconds transplants. Operative times and length of stay were equivalent between the subgroups. Surgical complication rates were similar in all groups (22.7% in 1st and 2nd transplants, and 27.2% in 3rd\/4th transplants). There was no significant difference in patient or graft survival over 5\u00a0years. Graft function was similar between transplant groups at 1, 3, and 5\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Third and fourth kidney transplants can be performed safely with similar outcomes to 1st and 2nd transplants. Kidney retransplantation from antibody\u2010incompatible donors may be appropriate for highly sensitized patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13104","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T01:56:48Z","timestamp":1504576608000},"source":"Crossref","is-referenced-by-count":5,"title":["Kidney retransplantation from <scp>HLA<\/scp>\u2010incompatible living donors: A single\u2010center study of 3rd\/4th transplants"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9351-6377","authenticated-orcid":false,"given":"James C.H.","family":"Barnes","sequence":"first","affiliation":[{"name":"Department of Transplant Surgery University Hospitals Coventry and Warwickshire NHS Trust  Coventry UK"},{"name":"Nuffield Department of Surgical Sciences University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Goodyear","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Worcestershire Acute Hospitals NHS Trust  Worcester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin E.A.","family":"Imray","sequence":"additional","affiliation":[{"name":"Sheffield Medical School University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"For Tai","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery University Hospitals Coventry and Warwickshire NHS Trust  Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habib S.","family":"Kashi","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery University Hospitals Coventry and Warwickshire NHS Trust  Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lam Chin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery University Hospitals Coventry and Warwickshire NHS Trust  Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Higgins","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery University Hospitals Coventry and Warwickshire NHS Trust  Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher H.E.","family":"Imray","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery University Hospitals Coventry and Warwickshire NHS Trust  Coventry UK"},{"name":"Warwick Medical School University of Warwick  Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412303"},{"key":"e_1_2_8_3_1","unstructured":"BradburyL.Annual Report on Kidney Transplantation.2015;http:\/\/www.odt.nhs.uk\/pdf\/organ_specific_report_kidney_2015.pdf. 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