{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:01:08Z","timestamp":1782475268725,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T00:00:00Z","timestamp":1509667200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied the causes and predictors of death\u2010censored kidney allograft failure among 1670 kidney recipients transplanted at our center in the corticosteroid\u2010free maintenance immunosuppression era. As of January 1, 2012, we identified 137 recipients with allograft failure; 130 of them (cases) were matched 1\u20101 for recipient age, calendar year of transplant, and donor type with 130 recipients with functioning grafts (controls). Median time to allograft failure was 29\u00a0months (interquartile range: 18\u201051). Physician\u2010validated and biopsy\u2010confirmed categories of allograft failure were as follows: acute rejection (21%), glomerular disease (19%), transplant glomerulopathy (13%), interstitial fibrosis tubular atrophy (10%), and polyomavirus\u2010associated nephropathy (7%). Graft failures were attributed to medical conditions in 21% and remained unresolved in 9%. Donor race, donor age, human leukocyte antigen mismatches, serum creatinine, urinary protein, acute cellular rejection, acute antibody\u2010mediated rejection, <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> viremia, and <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> viremia were associated with allograft failure. Independent predictors of allograft failure were acute cellular rejection (odds ratio: 18.31, 95% confidence interval: 5.28\u201063.45) and urine protein \u22651\u00a0g\/d within the first year post\u2010transplantation (5.85, 2.37\u201014.45). Serum creatinine \u22641.5\u00a0mg\/dL within the first year post\u2010transplantation reduced the odds (0.29, 0.13\u20100.64) of allograft failure. Our study has identified modifiable risk factors to reduce the burden of allograft failure.<\/jats:p>","DOI":"10.1111\/ctr.13117","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T14:59:55Z","timestamp":1505746795000},"source":"Crossref","is-referenced-by-count":14,"title":["Kidney allograft failure in the steroid\u2010free immunosuppression era: A matched case\u2010control study"],"prefix":"10.1111","volume":"31","author":[{"given":"Mohamad M.","family":"Alkadi","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension Department of Medicine New York Presbyterian Hospital\u2010Weill Cornell Medical Center New York NY USA"},{"name":"Department of Transplantation Medicine New York Presbyterian Hospital\u2010Weill Cornell Medical Center New York NY USA"},{"name":"Division of Nephrology Department of Medicine Hamad Medical Corporation Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Transplantation Surgery Department of Surgery New York Presbyterian Hospital\u2010Weill Cornell Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith J.","family":"Aull","sequence":"additional","affiliation":[{"name":"Division of Transplantation Surgery Department of Surgery New York Presbyterian Hospital\u2010Weill Cornell Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Department of Medicine New York Presbyterian Hospital\u2010Weill Cornell Medical Center New York NY USA"},{"name":"Department of Psychiatry Stony Brook University Stony Brook NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Department of Medicine New York Presbyterian Hospital\u2010Weill Cornell Medical Center New York NY USA"},{"name":"Department of Transplantation Medicine New York Presbyterian Hospital\u2010Weill Cornell Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Watkins","sequence":"additional","affiliation":[{"name":"Division of Transplantation Surgery Department of Surgery New York Presbyterian Hospital\u2010Weill Cornell Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun B.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Department of Medicine New York Presbyterian Hospital\u2010Weill Cornell Medical Center New York NY USA"},{"name":"Department of Transplantation Medicine New York Presbyterian Hospital\u2010Weill 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