{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T19:57:22Z","timestamp":1767211042470,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,26]],"date-time":"2017-11-26T00:00:00Z","timestamp":1511654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Delayed graft function (<jats:styled-content style=\"fixed-case\">DGF<\/jats:styled-content>) is very high in our center (70%\u201080%), and we usually receive a kidney for transplant after more than 22\u00a0hours of static cold ischemia time (<jats:styled-content style=\"fixed-case\">CIT<\/jats:styled-content>). Also, there is an inadequate care of the donors, contributing to a high rate of <jats:styled-content style=\"fixed-case\">DGF<\/jats:styled-content>. We decided to test whether machine perfusion (<jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>) after a <jats:styled-content style=\"fixed-case\">CIT<\/jats:styled-content> improved the outcome of our transplant patients. We analyzed the incidence of <jats:styled-content style=\"fixed-case\">DGF<\/jats:styled-content>, its duration, and the length of hospital stay (<jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>) in patients who received a kidney preserved with <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> after a <jats:styled-content style=\"fixed-case\">CIT<\/jats:styled-content> (hybrid perfusion\u2014<jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>). We included 54 deceased donors kidneys preserved with <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content> transplanted from Feb\/13 to Jul\/14, and compared them to 101 kidney transplants preserved by static cold storage (<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>) from Nov\/08 to May\/12. The median pumping time was 11\u00a0hours. <jats:styled-content style=\"fixed-case\">DGF<\/jats:styled-content> incidence was 61.1% vs 79.2% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), median <jats:styled-content style=\"fixed-case\">DGF<\/jats:styled-content> duration was 5 vs 11\u00a0days (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.001), and median <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content> was 13 vs 18\u00a0days (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.011), for the <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> group. The observed reduction of <jats:styled-content style=\"fixed-case\">DGF<\/jats:styled-content> with machine perfusion did not occur in donors over 50\u00a0years old. In the multivariate analysis, risk factors for <jats:styled-content style=\"fixed-case\">DGF<\/jats:styled-content>, adjusted for <jats:styled-content style=\"fixed-case\">CIT<\/jats:styled-content>, were donor age (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.04; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005) and the absence of use of <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.54; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.051). In conclusion, the use of <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content> contributed to faster recovery of renal function and to a shorter length of hospital stay.<\/jats:p>","DOI":"10.1111\/ctr.13130","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T15:52:39Z","timestamp":1507045959000},"source":"Crossref","is-referenced-by-count":22,"title":["Impact of machine perfusion after long static cold storage on delayed graft function incidence and duration and time to hospital discharge"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9703-3399","authenticated-orcid":false,"given":"Ana Cristina C.","family":"Matos","sequence":"first","affiliation":[{"name":"Renal Transplantation Division Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facio Roberto","family":"Requiao Moura","sequence":"additional","affiliation":[{"name":"Renal Transplantation Division Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Renal Transplantation Division Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Renal Transplantation Division Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Clarizia","sequence":"additional","affiliation":[{"name":"Renal Transplantation Division Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Ongaro","sequence":"additional","affiliation":[{"name":"Renal Transplantation Division Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelino Souza","family":"Dur\u00e3o","sequence":"additional","affiliation":[{"name":"Renal Transplantation Division Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"},{"name":"Department of Medicine\/Nephrology Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Pacheco\u2010Silva","sequence":"additional","affiliation":[{"name":"Renal Transplantation Division Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"},{"name":"Department of Medicine\/Nephrology Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft488"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2014.05.026"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.05.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.5935\/0101-2800.20130048"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.05.005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318279153c"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12579"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802289"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.07.133"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1111038"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.04.013"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2011.01232.x"},{"key":"e_1_2_6_14_1","first-page":"6","article-title":"Dados num\u00e9ricos da doa\u00e7\u00e3o de \u00f3rg\u00e3os e transplantes realizados por Estado e Institui\u00e7\u00e3o no per\u00edodo; 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