{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:49:35Z","timestamp":1772459375181,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:00:00Z","timestamp":1515110400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Astellas Pharma GmbH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study assessed adherence to prolonged\u2010release tacrolimus (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\u2010T)\u2010based immunosuppression during routine maintenance of renal transplant recipients in Germany. Patients had received <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\u2010T for \u22651\u00a0month at inclusion. Data were collected during four visits (V): baseline (V1), 6 (V2), 12 (V3), and 18 (V4) months. Composite primary endpoint: nonadherence at V4, defined as self\u2010reported nonadherence on the Basel Assessment of Adherence with Immunosuppressive Medication Scale (<jats:styled-content style=\"fixed-case\">BAASIS<\/jats:styled-content><jats:sup>\u00a9<\/jats:sup>), investigator\u2010rated nonadherence, and\/or V4 tacrolimus trough level outside a predefined range. Secondary endpoints: individual <jats:styled-content style=\"fixed-case\">BAASIS<\/jats:styled-content> items, incidence of rejection, kidney function, and safety. Overall, 153 adult kidney recipients (mean [standard deviation] time post\u2010transplant 5.8 [4.6]\u00a0years) were included. Nonadherence was high at V4 (67.7% [95% confidence interval 58.9%, 75.6%]). Medication\u2010taking adherence was 86.9% and 91.3% at V1 and V4, respectively; adherence to timing of medication intake was 58.2% and 58.3%, with little evidence of missed doses\/drug holidays. Investigators rated adherence \u201cgood\u201d in 85.6% of patients (V4). Two (1.3%) patients had acute rejection episodes. Kidney function remained stable (mean creatinine clearance, V1: 62.1\u00a0mL\/min; V4: 65.3\u00a0mL\/min). Investigators rated effectiveness of <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\u2010T as \u201cvery good\u201d\/\u201cgood\u201d in 91.5% of patients. Most patients (94.7%) found <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\u2010T dosing more convenient than immediate\u2010release tacrolimus. <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\u2010T was well tolerated with high medication persistence.<\/jats:p>","DOI":"10.1111\/ctr.13142","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T10:36:39Z","timestamp":1508495799000},"source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of adherence and tolerability of prolonged\u2010release tacrolimus (Advagraf\u2122) in kidney transplant patients in Germany: A multicenter, noninterventional study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9440-6196","authenticated-orcid":false,"given":"Lukas J.","family":"Lehner","sequence":"first","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Reinke","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan H.","family":"H\u00f6rstrup","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Intensive Care Medicine Humboldt\u2010University  Berlin Germany"},{"name":"KfH Nierenzentrum Berlin\u2010Charlottenburg  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Rath","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine Westpfalz\u2010Klinikum  Kaiserslautern Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Suwelack","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 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