{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:57:12Z","timestamp":1789952232187,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["203930\/B\/16\/Z"],"award-info":[{"award-number":["203930\/B\/16\/Z"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Primary focal segmental glomerular sclerosis (p\u2010FSGS<\/jats:styled-content>) is commonly complicated by recurrence (r\u2010FSGS<\/jats:styled-content>) post\u2010transplantation. Our objective was to describe Irish outcomes for transplantation after end\u2010stage renal disease (ESRD<\/jats:styled-content>) due to p\u2010FSGS<\/jats:styled-content>, specifically rates of, and treatments for, r\u2010FSGS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Patients and Methods<\/jats:title>Irish patients with biopsy\u2010proven FSGS<\/jats:styled-content> were identified from the Irish National Kidney Transplant database (1982\u20102015). Medical record review was performed to identify predictors of r\u2010FSGS<\/jats:styled-content> and treatments for r\u2010FSGS<\/jats:styled-content>. Transplant outcomes were compared to outcomes in all renal transplants performed during the same time period using registry data. Demographic and clinical predictors of r\u2010FSGS<\/jats:styled-content> were identified. Statistical analysis was performed using Stata (version 13, College Station, TX, USA).<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010eight transplant recipients had biopsy\u2010proven p\u2010FSGS<\/jats:styled-content>, 16 received a second transplant. A total of 3846 transplants formed the comparator group. r\u2010FSGS<\/jats:styled-content> complicated 60.5% (23\/38) of first transplants. Eighty\u2010six percent (10\/12) of patients with previous r\u2010FSGS<\/jats:styled-content> developed recurrent disease after further transplantation.<\/jats:p>Patients with p\u2010FSGS<\/jats:styled-content> receiving a first renal transplant had higher rate of graft failure than those with another cause of ESRD<\/jats:styled-content> (HR<\/jats:styled-content> 1.9, 95% CI<\/jats:styled-content> 1.152\u20103.139).<\/jats:p>Sixteen patients received immunotherapy for r\u2010FSGS<\/jats:styled-content>; 12 (86%) had at least partial response, but two (14%) developed significant complications.<\/jats:p><\/jats:sec>Discussion<\/jats:title>We demonstrate high rates of r\u2010FSGS<\/jats:styled-content> and describe modest success from with treatments for r\u2010FSGS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13152","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:06:39Z","timestamp":1510185999000},"source":"Crossref","is-referenced-by-count":23,"title":["Renal transplant outcomes in primary FSGS<\/scp> compared with other recipients and risk factors for recurrence: A national review of the Irish Transplant Registry"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7769-5152","authenticated-orcid":false,"given":"Sarah","family":"Cormican","sequence":"first","affiliation":[{"name":"Nephrology Beaumont Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7277-2171","authenticated-orcid":false,"given":"Claire","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Nephrology and Transplantation Beaumont Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"O'Kelly","sequence":"additional","affiliation":[{"name":"Nephrology and Transplantation Beaumont Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Doyle","sequence":"additional","affiliation":[{"name":"Histopathology Beaumont Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Dorman","sequence":"additional","affiliation":[{"name":"Histopathology Beaumont Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atif","family":"Awan","sequence":"additional","affiliation":[{"name":"Temple Street Children\u2019s University Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Conlon","sequence":"additional","affiliation":[{"name":"Nephrology and Transplantation Beaumont Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00710805"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(04)01081-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012040389"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"68vi","DOI":"10.1093\/ndt\/gfg1068","article-title":"Recurrent disease in renal transplants","volume":"18","author":"Newstead C","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2411"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008538"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31819f12be"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/ndt\/gfp538","article-title":"Recurrence of focal segmental glomerular sclerosis (FSGS) after renal transplantation","volume":"25","author":"Ponticelli C","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5414\/CN107653","article-title":"Glomerular disease recurrence in second and subsequent kidney transplants","volume":"79","author":"Kennedy C","year":"2013","journal-title":"Clin Nephrol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01462.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01112.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3295618"},{"key":"e_1_2_7_14_1","unstructured":"National Kidney Transplant Service Ireland.Annual Report 2015. Dublin: Beaumont Hospital; 2016.http:\/\/www.beaumont.ie\/media\/2015-National-Kidney-Transplant-Service-Annual-Report1.pdf. Accessed May 8 2017."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.21311"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03060316"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/ndt\/gfk005","article-title":"Risk factors and outcome of focal and segmental glomerulosclerosis recurrence in adult renal transplant recipients","volume":"21","author":"Pardon A","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-47"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2009.00977.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001160"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00867682"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00494.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.30111.x"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T06:01:00Z","timestamp":1695967260000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,4]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/ctr.13152"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13152","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,4]]},"article-number":"e13152"}}