{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T20:58:41Z","timestamp":1771102721173,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:00:00Z","timestamp":1515369600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Frailty assessment has become an integral part of the evaluation of potential candidates for heart transplantation and ventricular assist device (<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x\/<jats:styled-content style=\"fixed-case\">VAD<\/jats:styled-content>). The impact of frailty, as a heart failure risk factor or to identify those who will derive the greatest benefit with <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x\/<jats:styled-content style=\"fixed-case\">VAD<\/jats:styled-content> remains unclear. The aim of this study was to evaluate the independent prognostic relevance of frailty assessment from peak oxygen consumption (peak <jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content><jats:sub>2<\/jats:sub>) or B\u2010type natriuretic peptide (<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>) on mortality in patients referred for advanced heart failure therapies. Frailty was measured using modified Fried frailty criteria. In 201 consecutive patients, during a median follow\u2010up of 17.5\u00a0months (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 11\u201029.2), there were 25 (12.4%) deaths. One\u2010year survival was 100%, 94%, and 78% in nonfrail, prefrail, and frail patients, respectively (log rank <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.0001). Frailty was associated with a twofold increase risk of death (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2.01, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.42\u20102.84). When adjusted for <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> or peak <jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content><jats:sub>2<\/jats:sub>, frailty was not associated with a significant risk of all\u2010cause death. However, when peak <jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content><jats:sub>2<\/jats:sub> is stratified into two categories (\u226512\u00a0mL\/kg\/min vs &lt;12\u00a0mL\/kg\/min), frailty was associated with increased mortality in patients with a lower peak <jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content><jats:sub>2<\/jats:sub> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.72, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006).<\/jats:p>","DOI":"10.1111\/ctr.13158","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T06:06:40Z","timestamp":1511417200000},"source":"Crossref","is-referenced-by-count":22,"title":["The prognostic significance of frailty compared to peak oxygen consumption and B\u2010type natriuretic peptide in patients with advanced heart failure"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3288-7393","authenticated-orcid":false,"given":"Yasbanoo","family":"Moayedi","sequence":"first","affiliation":[{"name":"Heart Failure and Heart Transplant Program Stanford University  Stanford CA USA"},{"name":"Ted Rogers Centre of Excellence in Heart Function Peter Munk Cardiac Centre University Health Network  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6118-4200","authenticated-orcid":false,"given":"Juan G.","family":"Duero Posada","sequence":"additional","affiliation":[{"name":"Ted Rogers Centre of Excellence in Heart Function Peter Munk Cardiac Centre University Health Network  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1029-1812","authenticated-orcid":false,"given":"Farid","family":"Foroutan","sequence":"additional","affiliation":[{"name":"Ted Rogers Centre of Excellence in Heart Function Peter Munk Cardiac Centre University Health Network  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1523-4286","authenticated-orcid":false,"given":"Livia A.","family":"Goldraich","sequence":"additional","affiliation":[{"name":"Heart Failure and Heart Transplant Program Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-8338","authenticated-orcid":false,"given":"Ana C.","family":"Alba","sequence":"additional","affiliation":[{"name":"Ted Rogers Centre of Excellence in Heart Function Peter Munk Cardiac Centre University Health Network  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-6399","authenticated-orcid":false,"given":"Jane","family":"MacIver","sequence":"additional","affiliation":[{"name":"Ted Rogers Centre of Excellence in Heart Function Peter Munk Cardiac Centre University Health Network  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4384-3027","authenticated-orcid":false,"given":"Heather J.","family":"Ross","sequence":"additional","affiliation":[{"name":"Ted Rogers Centre of Excellence in Heart Function Peter Munk Cardiac Centre University Health Network  Toronto ON 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