{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:44:51Z","timestamp":1778618691327,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T00:00:00Z","timestamp":1514160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008558","name":"Brody School of Medicine","doi-asserted-by":"publisher","award":["Brody Brothers Seed Grant 2016"],"award-info":[{"award-number":["Brody Brothers Seed Grant 2016"]}],"id":[{"id":"10.13039\/100008558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>Little is known about the impact of CYP<\/jats:styled-content>3A5 polymorphisms on transplantation outcomes among African American (AA<\/jats:styled-content>) kidney transplant recipients (KTRs). To assess this issue, clinical outcomes were compared between AA CYP<\/jats:styled-content>3A5*1 expressers and nonexpressers. This retrospective cohort study analyzed AA<\/jats:styled-content> KTRs. Biopsy\u2010proven acute rejection (BPAR<\/jats:styled-content>), delayed graft function (DGF<\/jats:styled-content>), glomerular filtration rate (GFR<\/jats:styled-content>), infections, and tacrolimus dosing requirements were examined in 106 immunologically high\u2010risk AA<\/jats:styled-content> kidney transplant patients over a 2\u2010year follow\u2010up period. In CYP<\/jats:styled-content>3A5*1 expressers compared to nonexpressers, the incidence of BPAR<\/jats:styled-content> was significantly higher in the first 6\u00a0months (13% vs 0%; P<\/jats:italic>\u00a0=\u00a0.016) compared to 24\u00a0months (13% vs 7%; P<\/jats:italic>\u00a0=\u00a0.521). Tacrolimus total daily dose at first therapeutic level was significantly higher in CYP<\/jats:styled-content>3A5*1 expressers (12\u00a0mg\/day) compared to nonexpressers (8\u00a0mg\/day; P<\/jats:italic>\u00a0<\u00a0.001). Compared to CYP<\/jats:styled-content>3A5*1 nonexpressers, DGF<\/jats:styled-content> incidence was significantly higher among CYP<\/jats:styled-content>3A5*1 expressers (27.6% vs 6.7%; P<\/jats:italic>\u00a0=\u00a0.006). By contrast, median GFR<\/jats:styled-content> was significantly higher in CYP<\/jats:styled-content>3A5*1 expressers compared to nonexpressers (54.5\u00a0mL\/min vs 50.0\u00a0mL\/min; P\u00a0<\/jats:italic>=\u00a0.003) at 24\u00a0months. The findings from this retrospective study suggest that AA<\/jats:styled-content>s with CYP<\/jats:styled-content>3A5*1 expression require 50% more tacrolimus and have an increased incidence of DGF<\/jats:styled-content> and acute rejection.<\/jats:p>","DOI":"10.1111\/ctr.13162","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T22:42:39Z","timestamp":1511304159000},"source":"Crossref","is-referenced-by-count":23,"title":["Impact of CYP<\/scp>3A5 genomic variances on clinical outcomes among African American kidney transplant recipients"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-0924","authenticated-orcid":false,"given":"Tomefa E.","family":"Asempa","sequence":"first","affiliation":[{"name":"Department of Pharmacy Vidant Medical Center Greenville NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorita M.","family":"Rebellato","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine The Brody School of Medicine at East Carolina University Greenville NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Hudson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics East Carolina University Greenville NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Briley","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine The Brody School of Medicine at East Carolina University Greenville NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela Q.","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Department of Surgery Vidant Medical Center Greenville NC 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