{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:55:47Z","timestamp":1758635747910,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Calcineurin inhibitor (<jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>) toxicity leads to end\u2010stage renal disease in almost half of long\u2010term survivors after lung transplantation, some of them receiving kidney transplants. Little is known about the outcomes of kidney and lung allograft function following kidney after lung transplantation (<jats:styled-content style=\"fixed-case\">KALTPL<\/jats:styled-content>) in the modern era. We retrospectively analyzed a group of 13 consecutive patients who received a <jats:styled-content style=\"fixed-case\">KALTPL<\/jats:styled-content> with respect to their renal and pulmonary function and immunological evolution over 2\u00a0years. We documented a stable evolution of forced expiratory volume in 1 second (<jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>1) after <jats:styled-content style=\"fixed-case\">KALTPL<\/jats:styled-content> in most patients as well as an excellent kidney graft during the 2\u2010year follow\u2010up period. In our small cohort, living donations showed a significantly higher estimated glomerular filtration rate compared to deceased donation (75.7 compared to 41.6\u00a0mL\/min). Patients who received a preemptive <jats:styled-content style=\"fixed-case\">KALTPL<\/jats:styled-content> were more likely to improve their lung function after <jats:styled-content style=\"fixed-case\">KALTPL<\/jats:styled-content>. Four patients developed de novo donor\u2010specific antibodies (<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>) against the kidney graft. There were no <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> against shared antigens from the lung allograft. De novo <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> did not lead to graft loss in any patient. All 13 patients survived the first 24\u00a0months after <jats:styled-content style=\"fixed-case\">KALTPL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ctr.13169","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T07:46:40Z","timestamp":1512114400000},"source":"Crossref","is-referenced-by-count":4,"title":["Evolution of lung and kidney allograft function in patients receiving kidney after lung transplantation"],"prefix":"10.1111","volume":"32","author":[{"given":"Nina T.","family":"Weber","sequence":"first","affiliation":[{"name":"Division of Nephrology University Hospital  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Bonani","sequence":"additional","affiliation":[{"name":"Division of Nephrology University Hospital  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8409-5646","authenticated-orcid":false,"given":"Christian","family":"Benden","sequence":"additional","affiliation":[{"name":"Division of Pulmonology University Hospital  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schleich","sequence":"additional","affiliation":[{"name":"Institute of Nephrology Stadtspital Waid  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Fehr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cantonal Hospital Graub\u00fcnden  Chur Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Division of Nephrology University Hospital  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5404-7566","authenticated-orcid":false,"given":"Mac\u00e9 M.","family":"Schuurmans","sequence":"additional","affiliation":[{"name":"Division of Pulmonology University Hospital  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021744"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.05.064"},{"key":"e_1_2_6_4_1","first-page":"w13883","article-title":"Risk factors and outcome of expanded\u2010criteria donor kidney transplants in patients with low immunological risk","volume":"143","author":"Praehauser C","year":"2013","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_6_5_1","first-page":"w13836","article-title":"Zurich University Hospital lung transplantation programme: update 2012","volume":"143","author":"Inci I","year":"2013","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339345"},{"key":"e_1_2_6_7_1","first-page":"w13773","article-title":"Practical approach to early postoperative management of lung transplant recipients","volume":"143","author":"Schuurmans MM","year":"2013","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/138.4.837"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318169c29e"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31817059a1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.06.034"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T09:56:37Z","timestamp":1709718997000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,21]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/ctr.13169"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13169","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2017,12,21]]},"article-number":"e13169"}}