{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:29:33Z","timestamp":1753878573250,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Although cardiac rehabilitation is recommended for patients early after heart transplantation (<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x), adequate exercise effect cannot always be obtained, partly because in patients with chronic heart failure, exercise capacity is reduced due to malnutrition while waiting for <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x. This study aimed to investigate the relationships between exercise capacity and clinical variables, including nutritional indicators, early after <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Forty\u2010three <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x recipients were studied. The mean age at <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x was 38\u00a0\u00b1\u00a014\u00a0years, and 86% were male. We assessed the relationships between peak oxygen uptake (<jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content><jats:sub>2<\/jats:sub>) and clinical variables, including plasma B\u2010type natriuretic peptide (<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>), isometric knee extensor muscle strength (<jats:styled-content style=\"fixed-case\">KEMS<\/jats:styled-content>), and nutritional indicators within 1\u00a0week of their respective discharges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peak <jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content><jats:sub>2<\/jats:sub> correlated positively with isometric <jats:styled-content style=\"fixed-case\">KEMS<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.63, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) and negatively with <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> level (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.37, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.015). Of the nutritional indicators, only cholinesterase levels had a significant relationship with peak <jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content><jats:sub>2<\/jats:sub> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.34, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.028), whereas the Geriatric Nutritional Risk Index and the Controlling Nutritional Status scores did not. In multiple linear regression analysis, cholinesterase levels and isometric <jats:styled-content style=\"fixed-case\">KEMS<\/jats:styled-content> were independent predictors of peak <jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content><jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cholinesterase levels predicted exercise capacity early after <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13170","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T07:46:42Z","timestamp":1512114402000},"source":"Crossref","is-referenced-by-count":2,"title":["Cholinesterase levels predict exercise capacity in cardiac recipients early after transplantation"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1955-257X","authenticated-orcid":false,"given":"Kazufumi","family":"Kitagaki","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Rehabilitation National Cerebral and Cardiovascular Center  Suita Japan"},{"name":"Graduate School of Health Science Kobe University  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Rehabilitation National Cerebral and Cardiovascular Center  Suita Japan"},{"name":"Department of Cardiovascular Medicine National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei","family":"Ono","sequence":"additional","affiliation":[{"name":"Graduate School of Health Science Kobe University  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Rehabilitation National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Rehabilitation National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Rehabilitation National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Yanagi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Rehabilitation National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harumi","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Nursing National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Yanase","sequence":"additional","affiliation":[{"name":"Department of Transplant Medicine National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihide","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Transplant Medicine National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1253\/circj.CJ-16-0976"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1161\/01.CIR.85.4.1364"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1161\/01.CIR.98.18.1886"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1056\/NEJM199901283400404"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.4065\/77.12.1295"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1177\/0884533612457948"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1016\/j.eclnm.2009.10.006"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1093\/ajcn\/82.4.777"},{"key":"e_1_2_7_10_1","first-page":"38","article-title":"CONUT: a tool for Controlling Nutritional Status. 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