{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:54:24Z","timestamp":1783727664982,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T00:00:00Z","timestamp":1515283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Increased levels of angiotensin II<\/jats:styled-content> type 1 receptor (AT<\/jats:styled-content>1<\/jats:sub>R) antibody have been shown to be associated with allograft rejection. This study aims to determine the rate of development of antibody to AT<\/jats:styled-content>1<\/jats:sub>R after mechanical circulatory support device (MCS<\/jats:styled-content>) implantation, and if the development of strong binding AT<\/jats:styled-content>1<\/jats:sub>R antibodies is associated with survival.<\/jats:p><\/jats:sec>Methods<\/jats:title>Eighty\u2010eight patients who had one MCS<\/jats:styled-content> implantation were accessed based on serum availability. Mechanical circulatory support devices in this cohort included pneumatic bilateral paracorporeal ventricular assist device, continuous flow left ventricular assist device, and total artificial heart.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 88 patients, seven patients had AT<\/jats:styled-content>1<\/jats:sub>R antibodies \u226540\u00a0U\/mL preimplantation. For 81 patients who had AT<\/jats:styled-content>1<\/jats:sub>R antibodies <40\u00a0U\/mL, the median value was 8\u00a0U\/mL. Of these 81 patients, AT<\/jats:styled-content>1<\/jats:sub>R antibody levels in 55 (68%) patients reached the saturated concentration (\u226540\u00a0U\/mL) postimplantation (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.0001), with the highest percentage of patients with the saturated level of AT<\/jats:styled-content>1<\/jats:sub>R antibody observed in the pneumatic bilateral paracorporeal ventricular assist device group. Compared to patients without the saturated level of AT<\/jats:styled-content>1<\/jats:sub>R antibodies, patients with the saturated AT<\/jats:styled-content>1<\/jats:sub>R antibody level had lower 18\u2010month survival (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.040).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Mechanical circulatory support devices implantation significantly increases AT<\/jats:styled-content>1<\/jats:sub>R antibody levels. The saturated level of AT<\/jats:styled-content>1<\/jats:sub>R antibodies is associated with lower patient survival postimplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13178","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T21:50:16Z","timestamp":1513461016000},"source":"Crossref","is-referenced-by-count":21,"title":["Revealing a new mode of sensitization induced by mechanical circulatory support devices: Impact of anti\u2010AT<\/scp>1<\/sub>R antibodies"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7188-7855","authenticated-orcid":false,"given":"Xiaohai","family":"Zhang","sequence":"first","affiliation":[{"name":"HLA and Immunogenetics Laboratory Comprehensive Transplant Center Cedars\u2010Sinai Health System Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Mirocha","sequence":"additional","affiliation":[{"name":"Biostatistics Core Cedars\u2010Sinai Health System Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Aintablian","sequence":"additional","affiliation":[{"name":"California Heart Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Dimbil","sequence":"additional","affiliation":[{"name":"California Heart Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Moriguchi","sequence":"additional","affiliation":[{"name":"Cardiology Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Arabia","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon A.","family":"Kobashigawa","sequence":"additional","affiliation":[{"name":"Cardiology Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Reinsmoen","sequence":"additional","affiliation":[{"name":"HLA and Immunogenetics Laboratory Comprehensive Transplant Center Cedars\u2010Sinai Health System Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4106"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4457"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4503"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035717"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181fd97f1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318234b337"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31816f612a"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182692ad2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-636480"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivv344"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.08.014"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000436927.08026.a8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00440160064009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200109000-00008"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13178","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T09:56:18Z","timestamp":1709718978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,7]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/ctr.13178"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13178","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,7]]},"article-number":"e13178"}}