{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:30:12Z","timestamp":1753878612984,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T00:00:00Z","timestamp":1515715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>In single ventricle patients, aortopulmonary collaterals (APC<\/jats:styled-content>s) and pulmonary arteriovenous malformations (PAVM<\/jats:styled-content>s) following superior cavopulmonary shunt (CPS<\/jats:styled-content>) can complicate orthotopic heart transplant (OHT<\/jats:styled-content>) by cyanosis and hemoptysis. Although PAVM<\/jats:styled-content>s can regress with the restoration of hepatic venous flow to the pulmonary circulation, the effects of hypoxemia on the \u201cunconditioned\u201d allograft are not known.<\/jats:p><\/jats:sec>Cases<\/jats:title>Two patients with significant PAVM<\/jats:styled-content>s after CPS<\/jats:styled-content> were cyanotic following OHT<\/jats:styled-content>. One patient with predominantly unilateral left PAVM<\/jats:styled-content>s had arterial saturation levels less than 70% despite pulmonary vasodilators and ventilation. A custom flow restrictor\u2010covered stent was deployed in the pulmonary artery of the affected side, redirecting the blood flow to the contralateral lung, immediately improving cyanosis. When the PAVM<\/jats:styled-content>s regressed, the flow restrictor stent was dilated to eliminate the constriction. The second patient with PAVM<\/jats:styled-content>s had cyanosis and severe hemoptysis from APC<\/jats:styled-content>s post\u2010OHT<\/jats:styled-content>. The APC<\/jats:styled-content>s required an extensive coil embolization, while the cyanosis responded to oxygen and pulmonary vasodilators. Both recipients did well with gradual resolution of PAVM<\/jats:styled-content>s within 8\u00a0months.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Despite cyanosis from right\u2010to\u2010left intrapulmonary shunting, allograft function recovered. Novel transcatheter interventions can play a role in patients with significant APC<\/jats:styled-content>s or PAVM<\/jats:styled-content> following cardiac transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13183","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T08:16:39Z","timestamp":1514276199000},"source":"Crossref","is-referenced-by-count":0,"title":["A tale of two cases of pulmonary arteriovenous malformation: How they fared after cardiac transplantation"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-1470","authenticated-orcid":false,"given":"Bethany L.","family":"Wisotzkey","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology Johns Hopkins All Children\u2019s Hospital Saint Petersburg FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dari L.","family":"Magyar","sequence":"additional","affiliation":[{"name":"Department of 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