{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:44:44Z","timestamp":1784616284209,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunoglobulin A nephropathy (Ig<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>) is the most common primary glomerulonephritis; the reported recurrence rate of Ig<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> after renal transplantation is as high as 13%\u201050%. The impact of immunosuppressive therapy and steroid withdrawal on the risk of recurrence of Ig<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> is still under debate. We performed a retrospective single\u2010center study, selecting 123 kidney transplants (rtx) in 120 patients, between January 1995 and December 2012, with Ig<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> on the native kidney. In 51 of 123 transplants, at least one post\u2010transplantation biopsy for clinical indication was performed; in 28 of 51 transplants, Ig<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> recurrence (Ig<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>r) was demonstrated. This group (G1; N\u00a0=\u00a028) was compared with a group without Ig<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>r (G2; N\u00a0=\u00a023). In our study, clinically evident Ig<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>r rate was 54.9% (28\/51) on biopsied patients. At discharge, the use of the immunosuppressant drugs (tacrolimus, cyclosporine A, mycophenolate mofetil, azathioprine, <jats:styled-content style=\"fixed-case\">mT<\/jats:styled-content>or inhibitors) was not associated with an increased risk of Ig<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>r (<jats:italic>P<\/jats:italic>\u00a0=\u00a0<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>). At discharge, all patients were steroid treated. Neither the use of tacrolimus, mycophenolate mofetil, nor <jats:styled-content style=\"fixed-case\">mT<\/jats:styled-content>or inhibitors (<jats:styled-content style=\"fixed-case\">mT<\/jats:styled-content>ori) at biopsy time were associated with Ig<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>r. However, Ig<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>r was significantly higher in patients who experienced steroid withdrawal at any post\u2010transplantation time (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 7.7 <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). The median time to recurrence after steroid withdrawal was 59\u00a0months (min 4.18, max 113.2).<\/jats:p>","DOI":"10.1111\/ctr.13207","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T15:38:37Z","timestamp":1516289917000},"source":"Crossref","is-referenced-by-count":27,"title":["Recurrent IgA nephropathy after renal transplantation and steroid withdrawal"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3908-2205","authenticated-orcid":false,"given":"Maria Cristina","family":"Di Vico","sequence":"first","affiliation":[{"name":"Department of Medical Sciences Renal Transplantation Unit \u2018A. Vercellone\u2019 Division of Nephrology Dialysis and Transplantation Citt\u00e0 della Salute e della Scienza Hospital University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Messina","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Renal Transplantation Unit \u2018A. Vercellone\u2019 Division of Nephrology Dialysis and Transplantation Citt\u00e0 della Salute e della Scienza Hospital University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Fop","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Renal Transplantation Unit \u2018A. Vercellone\u2019 Division of Nephrology Dialysis and Transplantation Citt\u00e0 della Salute e della Scienza Hospital University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Barreca","sequence":"additional","affiliation":[{"name":"Division of Pathology Department of Medical Sciences Citt\u00e0 della Salute e della Scienza Hospital University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe Paolo","family":"Segoloni","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Renal Transplantation Unit \u2018A. Vercellone\u2019 Division of Nephrology Dialysis and Transplantation Citt\u00e0 della Salute e della Scienza Hospital University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7700-6350","authenticated-orcid":false,"given":"Luigi","family":"Biancone","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Renal Transplantation Unit \u2018A. Vercellone\u2019 Division of Nephrology Dialysis and Transplantation Citt\u00e0 della Salute e della Scienza Hospital University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1206793"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2007.10.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091756"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12255"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2004.01.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(88)80027-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr664"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02554.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp356"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000103869.08096.4F"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.9362"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003965.pub2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014070697"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2012.30"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-016-0314-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02442.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03667.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31821bf157"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12389"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03668.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00006.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12253"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft077"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01502.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs472"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181705ad4"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000264554.39645.74"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000188656.44326.53"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(96)90137-7"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13207","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T10:25:27Z","timestamp":1707733527000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,20]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/ctr.13207"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13207","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,20]]},"article-number":"e13207"}}