{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:47:13Z","timestamp":1789098433071,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000445"],"award-info":[{"award-number":["UL1TR000445"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The United Network for Organ Sharing system allocates deceased donor kidneys based on the kidney donor profile index (KDPI<\/jats:styled-content>), stratified as sequences (A\u00a0\u2264\u00a020%, B\u00a0>\u00a020\u2010<35%, C\u00a0\u2265\u00a035\u2010\u226485%, and D\u00a0>\u00a085%), with increasing KDPI<\/jats:styled-content> associated with decreased graft survival. While health\u2010related quality of life (HRQOL<\/jats:styled-content>) may improve after transplantation, the effect of donor kidney quality, reflected by KDPI<\/jats:styled-content> sequence, on post\u2010transplant HRQOL<\/jats:styled-content> has not been reported.<\/jats:p><\/jats:sec>Methods<\/jats:title>Health\u2010related quality of life was measured using the eight scales and physical and mental component summaries (PCS<\/jats:styled-content>, MCS<\/jats:styled-content>) of the SF<\/jats:styled-content>\u201036\u00ae<\/jats:sup> Health Survey. Multivariable mixed effects models that adjusted for age, gender, rejection, and previous transplant and analysis of variance methods tested the effects of time and KDPI<\/jats:styled-content> sequence on post\u2010transplant HRQOL<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 141 waitlisted adults and 505 recipients (>1700 observations) were included. Pretransplant PCS<\/jats:styled-content> and MCS<\/jats:styled-content> averaged, respectively, slightly below and within general population norms (GPN<\/jats:styled-content>; 40\u201060). At 31\u00a0\u00b1\u00a026\u00a0months post\u2010transplant, average PCS<\/jats:styled-content> (41\u00a0\u00b1\u00a011) and MCS<\/jats:styled-content> (51\u00a0\u00b1\u00a011), overall and within each KDPI<\/jats:styled-content> sequence, were within GPN<\/jats:styled-content>. KDPI<\/jats:styled-content> sequence was not related to post\u2010transplant HRQOL<\/jats:styled-content> (P<\/jats:italic>\u00a0>\u00a0.134) or its trajectory (interaction P<\/jats:italic>\u00a0>\u00a0.163).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Increasing KDPI<\/jats:styled-content> does not adversely affect the medium\u2010term values and trajectories of HRQOL<\/jats:styled-content> after kidney transplantation. This may reassure patients and centers when considering using high KDPI<\/jats:styled-content> kidneys.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13212","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T19:34:50Z","timestamp":1517254490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Increasing kidney donor profile index sequence does not adversely affect medium\u2010term health\u2010related quality of life after kidney transplantation"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6827-791X","authenticated-orcid":false,"given":"Rachel C.","family":"Forbes","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Kidney and Pancreas Transplantation Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene D.","family":"Feurer","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Biostatistics Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"LaNeve","sequence":"additional","affiliation":[{"name":"Vanderbilt Transplant Center Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice P.","family":"Concepcion","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology and Hypertension Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christianna","family":"Gamble","sequence":"additional","affiliation":[{"name":"Vanderbilt Transplant Center Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Rega","sequence":"additional","affiliation":[{"name":"Vanderbilt Transplant Center Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Wright","family":"Pinson","sequence":"additional","affiliation":[{"name":"Vanderbilt Transplant Center Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shaffer","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Kidney and Pancreas Transplantation Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"http:\/\/optn.transplant.hrsa.gov\/ContentDocuments\/OPTN_Policies.pdf. Accessed August 15 2017."},{"key":"e_1_2_8_3_1","unstructured":"https:\/\/optn.transplant.hrsa.gov\/media\/1512\/guide_to_calculating_interpreting_kdpi.pdf. Accessed August 15 2017."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13770"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.21.2726"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000181"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001057"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412303"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.09.019"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.01.016"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00193.x"},{"key":"e_1_2_8_12_1","first-page":"104","volume-title":"SF\u201036\u00ae Physical & Mental Health Summary Scales: A Manual for Users of Version 1","author":"Ware JE","year":"2001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200010000-00015"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000226070.74443.fb"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-016-0316-5"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-191"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2006.01745.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2009.11.009"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000846"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12198"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/152692480701700207"},{"key":"e_1_2_8_22_1","volume-title":"SF\u201036\u00ae Health Survey: Manual & Interpretation Guide","author":"Ware JE","year":"1993"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2007.00784.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLR.0000062554.74615.4C"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_8_26_1","unstructured":"HartA SmithJM SkearnsMA et\u00a0al.OPTN\/SRTR 2014 Annual Report Kidney.2014."},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000146258.79425.04"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000046259"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9905-8"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12785"},{"key":"e_1_2_8_31_1","unstructured":"http:\/\/optn.transplant.hrsa.gov\/ContentDocuments\/KDPI_Guide_Clinicians.pdf. Accessed August 15 2017."}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T10:26:11Z","timestamp":1707733571000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,30]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/ctr.13212"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13212","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,30]]},"assertion":[{"value":"2018-01-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13212"}}