{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:08:51Z","timestamp":1788847731231,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T00:00:00Z","timestamp":1519344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Virginia Lee Cook Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little data exist comparing outcomes following <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> nephropathy (<jats:styled-content style=\"fixed-case\">BKN<\/jats:styled-content>) vs acute rejection. We reviewed outcomes among recipients who had a primary diagnosis of biopsy\u2010proven <jats:styled-content style=\"fixed-case\">BKN<\/jats:styled-content> or rejection between 1 and 18\u00a0months post\u2010transplant. There were 96 cases of <jats:styled-content style=\"fixed-case\">BKN<\/jats:styled-content> and 256 cases of rejections. We compared outcomes of <jats:styled-content style=\"fixed-case\">BKN<\/jats:styled-content> with all rejection combined and also with cellular rejection. Seven of 256 (2.7%) patients developed <jats:styled-content style=\"fixed-case\">BKN<\/jats:styled-content> after treatment of rejection. Conversely, 8 of 96 (8.3%) developed rejection after <jats:styled-content style=\"fixed-case\">BKN<\/jats:styled-content>. The <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> at time of diagnosis in the <jats:styled-content style=\"fixed-case\">BKN<\/jats:styled-content> group (33.7\u00a0\u00b1\u00a012.6) was lower than the rejection group (44.8\u00a0\u00b1\u00a023.3, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> at 6\u00a0months after diagnosis of <jats:styled-content style=\"fixed-case\">BKN<\/jats:styled-content> was 32.7\u00a0\u00b1\u00a014.9 and for rejection was 48.8\u00a0\u00b1\u00a020.7 (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.001). The mean <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> at 3\u00a0years postdiagnosis was 41.6\u00a0\u00b1\u00a018.5 in <jats:styled-content style=\"fixed-case\">BKN<\/jats:styled-content> and 53\u00a0\u00b1\u00a021.3 for rejection (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). The graft failure incidence rates were similar between 2 groups. A similar pattern was observed comparing <jats:styled-content style=\"fixed-case\">BKN<\/jats:styled-content> with cellular rejection. While the difference in rate of graft loss between <jats:styled-content style=\"fixed-case\">BKN<\/jats:styled-content> and rejection did not reach statistical significance, kidney function up to 3\u00a0years after diagnosis was worse for <jats:styled-content style=\"fixed-case\">BKN<\/jats:styled-content> than for rejection, suggesting that <jats:styled-content style=\"fixed-case\">BKN<\/jats:styled-content> is at least as damaging to kidneys as rejection.<\/jats:p>","DOI":"10.1111\/ctr.13216","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T23:26:38Z","timestamp":1517613998000},"source":"Crossref","is-referenced-by-count":35,"title":["Which is more nephrotoxic for kidney transplants: <scp>BK<\/scp> nephropathy or rejection?"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-7465","authenticated-orcid":false,"given":"Sandesh","family":"Parajuli","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad C.","family":"Astor","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison WI USA"},{"name":"Department of Population Health Sciences University of Wisconsin School of Medicine and Public Health  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dixon","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery University of Wisconsin Hospital and Clinics  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0175-6825","authenticated-orcid":false,"given":"Brenda","family":"Muth","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetika","family":"Garg","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjang","family":"Djamali","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3326-8583","authenticated-orcid":false,"given":"Didier A.","family":"Mandelbrot","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00920207"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01096.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200010150-00018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.03.017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2011.01633.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13661"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670000461"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000054"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12110"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02770707"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.krcp.2015.07.004"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01371005"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03310.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12589"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02519.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq730"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04291.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03757.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020439"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2001.150404.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu023"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318282ba83"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318197c17d"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.01.271"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12530"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016030285"}],"container-title":["Clinical 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