{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:16:32Z","timestamp":1785525392808,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Trans\u2010bronchial forceps biopsy (<jats:styled-content style=\"fixed-case\">TBFB<\/jats:styled-content>) is the gold standard to establish the presence of allograft rejection or infection after lung transplantation. We aimed to analyze the diagnostic yield and safety of trans\u2010bronchial cryobiopsy (<jats:styled-content style=\"fixed-case\">TBCB<\/jats:styled-content>) in lung allografts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of 402 <jats:styled-content style=\"fixed-case\">TBB<\/jats:styled-content> procedures in 362 lung recipients was performed between 2011 and 2016. Half of the cases (201) were performed by <jats:styled-content style=\"fixed-case\">TBCB<\/jats:styled-content> and the other half by <jats:styled-content style=\"fixed-case\">TBFB<\/jats:styled-content>. One hundred random slides of <jats:styled-content style=\"fixed-case\">TBB<\/jats:styled-content> specimens from lung allografts were reviewed for artifacts, bleeding, and histological evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both <jats:styled-content style=\"fixed-case\">TBB<\/jats:styled-content> groups were comparable in age, gender distribution, and time following transplantation. Acute rejection was diagnosed in 21.9% of the <jats:styled-content style=\"fixed-case\">TBCB<\/jats:styled-content> group vs 14.9% in the <jats:styled-content style=\"fixed-case\">TBFB<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.09) and only 2 cases (1%) of nondiagnostic tissue in <jats:styled-content style=\"fixed-case\">TBCB<\/jats:styled-content> group and 4 cases (2%) in <jats:styled-content style=\"fixed-case\">TBFB<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.685). Complications of pneumothorax and bleeding occurred in 9 (4.5%) vs 8 (4%) and 5 (2.5%) vs 4 (2%) in <jats:styled-content style=\"fixed-case\">TBCB<\/jats:styled-content> vs <jats:styled-content style=\"fixed-case\">TBFB<\/jats:styled-content> groups, respectively. The <jats:styled-content style=\"fixed-case\">TBCB<\/jats:styled-content> specimens were larger than <jats:styled-content style=\"fixed-case\">TBFB<\/jats:styled-content> (average 16.6 vs 6.6\u00a0mm<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Crush and bleeding artifacts were seen in 11 (22%) and 23 (46%) of <jats:styled-content style=\"fixed-case\">TBFB<\/jats:styled-content>, respectively, yet none in <jats:styled-content style=\"fixed-case\">TBCB<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Trans\u2010bronchial cryobiopsy is safe and effective for diagnosis of lung allograft rejection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13221","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T03:32:41Z","timestamp":1518492761000},"source":"Crossref","is-referenced-by-count":37,"title":["Efficacy and safety of trans\u2010bronchial cryo in comparison with forceps biopsy in lung allograft recipients: Analysis of 402 procedures"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6994-4451","authenticated-orcid":false,"given":"Evgeni","family":"Gershman","sequence":"first","affiliation":[{"name":"Rabin Medical Center Pulmonary Institute Belinson Campus  Petah Tikva Israel"},{"name":"Sackler School of Medicine Medical Faculty Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ridman","sequence":"additional","affiliation":[{"name":"Rabin Medical Center Pulmonary Institute Belinson Campus  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Fridel","sequence":"additional","affiliation":[{"name":"Rabin Medical Center Pathology Institute Belinson Campus  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osnat","family":"Shtraichman","sequence":"additional","affiliation":[{"name":"Rabin Medical Center Pulmonary Institute Belinson Campus  Petah Tikva Israel"},{"name":"Sackler School of Medicine Medical Faculty Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barak","family":"Pertzov","sequence":"additional","affiliation":[{"name":"Rabin Medical Center Pulmonary Institute Belinson Campus  Petah Tikva Israel"},{"name":"Sackler School of Medicine Medical Faculty Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Rosengarten","sequence":"additional","affiliation":[{"name":"Rabin Medical Center Pulmonary Institute Belinson Campus  Petah Tikva Israel"},{"name":"Sackler School of Medicine Medical Faculty Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader Abdel","family":"Rahman","sequence":"additional","affiliation":[{"name":"Rabin Medical Center Pulmonary Institute Belinson Campus  Petah Tikva Israel"},{"name":"Sackler School of Medicine Medical Faculty Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorit","family":"Shitenberg","sequence":"additional","affiliation":[{"name":"Rabin Medical Center Pulmonary Institute Belinson Campus  Petah Tikva Israel"},{"name":"Sackler School of Medicine Medical Faculty Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mordechai R.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Rabin Medical Center Pulmonary Institute Belinson Campus  Petah Tikva Israel"},{"name":"Sackler School of Medicine Medical Faculty Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Ministry of Health State of Israel\/Organ Transplants\u2019 2016 \u2010 Medical Advances and Advanced Technology\/.http:\/\/www.health.gov.il\/. 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